grant
Characterizing Biological Aging for Heart and Lung Diseases Using Multi-omics Ageotypes
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 19 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025Active Follow-upAddressAdvisory CommitteesAgeAgingAlgorithmsBioinformaticsBiologicalBiological AgingCardiac DiseasesCardiac DisordersCausalityCell AgingCell SenescenceCellular AgingCellular SenescenceChronicChronic DiseaseChronic IllnessClinical DataClinical ManagementCommunicationComplexComputerized Medical RecordDataData SetDevelopmentDevelopment PlansDiseaseDisease OutcomeDisorderElectronic Medical RecordEnvironmental ExposureEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthicsEtiologyExhibitsFoundationsFutureGeneticGenomicsGoalsHealthHeart DiseasesHospitalsIncidenceIndividualInflammatory ResponseInvestigatorsKnowledgeLaboratoriesLung DiseasesMachine LearningMassachusettsMeasurementMeasuresMedical RecordsMedicineMentorsMentorshipMethodologyMethodsMolecularMolecular FingerprintingMolecular ProfilingMorbidityMorbidity - disease rateMultiomic DataNetwork-basedOutcomeOxidative StressPathway interactionsPersonalized medical approachPhenotypePopulationPrevalencePreventative strategyPreventionPrevention strategyPreventive strategyProcessPublic HealthPulmonary DiseasesPulmonary DisorderReplicative SenescenceResearchResearch DesignResearch PersonnelResearchersRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderSample SizeSingle Base PolymorphismSingle Nucleotide PolymorphismStudy TypeTask ForcesTechniquesTimeTrainingVariantVariationWomanWorkactive followupadvisory teamage associated chronic conditionage associated chronic diseaseage associated chronic disorderage associated chronic health conditionage associated chronic illnessage associated heart diseaseage associated heart disorderage related chronic conditionage related chronic diseaseage related chronic disorderage related chronic health conditionage related chronic illnessage related heart diseaseage related pathwaysaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging associatedaging associated mechanismaging mechanismaging pathwayaging populationaging processaging relatedaging related cardiac diseaseaging related mechanismaging related pathwaysbiobankbiologicbiological mechanism of agebiological pathways of agebiological process of agebiorepositorycareercareer developmentcausationchronic disorderclinical significanceclinically significantcohortdevelopmentaldisease causationdisease heterogeneitydisease of the lungdisease phenotypedisorder of the lungentire genomeepidemiologicepidemiologicalepigeneticallyepigenomicsethicalfollow upfollow-upfollowed upfollowupfull genomegenome sequencinghealthy aginghealthy human agingheart disorderimprovedindividualized approachindividualized preventioninsightlung disordermachine based learningmechanism regulating agingmechanisms involved in agingmedical collegemedical schoolsmetabolism measurementmetabolomicsmetabonomicsmolecular profilemolecular signaturemortalitymultiomicsmultiple omic datamultiple omicsnovelpanomicspathwaypathway involved in agingpersonalized approachpersonalized health carepersonalized preventionpopulation agingprecision approachprecision health careprecision preventionpreventpreventingreplicative agingschool of medicinesingle nucleotide variantskillsstatisticsstudy designtailored approachtreatment strategyunsupervised clusteringwhole genome
Description preview
PROJECT SUMMARY/ABSTRACT
As the aging population continues to grow worldwide, age-related chronic heart and lung diseases have become
an increasingly serious public health issue. Consequently, understanding the relationships between aging and
these diseases is crucial for effective prevention and treatment strategies. However, the complexity of…
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