grant
Characterization and Modulation of Functional Connectivity and Fear Extinction Abnormalities in Obsessive-Compulsive Disorder
NIHUS FederalResearch GrantFY202521+ years oldAccelerationAdultAdult HumanAllelism TestAnodesAnteriorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBrainBrain Nervous SystemCell Communication and SignalingCell SignalingCentral LobeCirculatory CollapseClinicalClinical TrialsCognition TherapyCognitive PsychotherapyCognitive TherapyCognitive treatmentCommunitiesComplementation TestConditioning TherapyDataDiagnosisDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyElectrodermal ResponseEncephalonExpectancyExperimental TherapiesExposure toExtinctionFearFrightFunctional MRIFunctional Magnetic Resonance ImagingGalvanic Skin ResponseGenetic Complementation TestInsulaInsula of ReilIntracellular Communication and SignalingInvestigational TherapiesInvestigational TreatmentsIsland of ReilLearningLiteratureMeasuresMedialMemory DeficitMemory impairmentMethodsNeurophysiology - biologic functionObsessive-Compulsive DisorderObsessive-Compulsive NeurosisPTSDParticipantPatientsPatternPersonsPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrefrontal CortexPreventionProceduresProcessPsychogalvanic ReflexPsychopathologyPsychotherapyRandomizedRecoveryReinforcement ScheduleReportingResearchRestSafetySamplingScanningShockSignal TransductionSignal Transduction SystemsSignalingSkin Electric ConductanceStandardizationStimulusSymptomsTestingTherapeuticTrainingTrans Testabnormal psychologyadulthoodanxiousbehavior interventionbehavioral interventionbiological signal transductionbrain circuitrycingulate cortexcirculatory shockcognitive behavior interventioncognitive behavior modificationcognitive behavior therapycognitive behavioral interventioncognitive behavioral modificationcognitive behavioral therapycognitive behavioral treatmentcomplementation analysiscomplementation approachconditioned fearconditioningdesigndesigningexperimentexperimental researchexperimental studyexperimental therapeutic agentsexperimental therapeuticsexperimentsfMRIfMRI scanfear conditioningfunctional MRI scanfunctional magnetic resonance imaging scanin vivoinnovateinnovationinnovativelearning extinctionlong-term memorymemory dysfunctionmemory processmemory processingneuralneural functionpost-trauma stress disorderposttrauma stress disorderrandomisationrandomizationrandomly assignedresponsescreeningscreeningsshockssignal processingskin conductancetherapeutic targettherapy responderstranscranial direct current stimulationtraumatic neurosistreatment choicetreatment respondersvolunteer
Description preview
ABSTRACT
Approximately 60% of patients with obsessive-compulsive disorder (OCD) respond to the psychotherapy of
choice, exposure and response prevention (ERP). Unfortunately, troubling symptoms persist for most patients,
even treatment responders. ERP is believed to depend on safety learning and engagement of related brain
circuitry. OCD patients…
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