grant
Cerebrovascular reactivity as a VCID biomarker in CADASIL
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 30 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldAD related dementiaADRDAdultAdult HumanAdventitial CellAgeAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmericanApoplexyArterial DisorderArteriesArteriopathyArteriosclerotic DementiaBinswanger DiseaseBinswanger EncephalopathyBiological MarkersBlood VesselsBrainBrain Nervous SystemBrain TIABrain Vascular AccidentBrain Vascular reactivityCO2Carbon DioxideCarbonic AnhydrideCerebral StrokeCerebral small vessel diseaseCerebrovascular ApoplexyCerebrovascular StrokeCerebrumChronic Progressive Subcortical EncephalopathyClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDNA mutationDataData CollectionDevelopmentDiseaseDisorderDisturbance in cognitionDrosophila Homolog of NOTCH 3DysfunctionEncephalonFrequenciesFunctional disorderFunctional impairmentFundingGene AlterationGene MutationGeneticGenetic ChangeGenetic defectGenetic mutationHealthHeritabilityHumanImpaired cognitionImpairmentKnowledgeLacunar InfarctionsLeiomyocyteLife CycleLife Cycle StagesLightLinkLong-term cohortLongitudinal cohortMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMicrovascular DysfunctionMigraineMigraine HeadacheModelingModern ManMotor SkillsMutationNINDSNMR ImagingNMR TomographyNOTCH3NOTCH3 geneNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNational Institutes of HealthNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingOrphan DiseaseParticipantPathogenesisPatientsPericapillary CellPericytesPerivascular CellPhenotypePhotoradiationPhysiologicPhysiologicalPhysiopathologyProcessR-Series Research ProjectsR01 MechanismR01 ProgramRare DiseasesRare DisorderRecommendationResearch GrantsResearch Project GrantsResearch ProjectsRoleRouget CellsSeizuresSensitivity and SpecificitySeveritiesSeverity of illnessSiteSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSourceStimulusStrokeSubcortical Arteriosclerotic EncephalopathySubcortical InfarctionsSubcortical InfarctsSubcortical LeukoencephalopathySymptomsTransient Ischemic AttackUnited States National Institutes of HealthVariantVariationVascular DementiaVascular Smooth MuscleWhite Matter HyperintensityWorkZeugmatographyadulthoodagesautosomebio-markersbiologic markerbiomarkerbrain attackbrain vascular healthcandidate biomarkercandidate markercardiac disease induced cognitive impairmentcerebralcerebral small vessel disordercerebral vascular accidentcerebral vascular reactivitycerebrovascular accidentcerebrovascular contribution to cognitive impairment and dementiacerebrovascular contributions to dementiacerebrovascular healthcerebrovascular reactivityclinical validationcognitive dysfunctioncognitive losscohortdecline in functiondecline in functional statusdepressiondevelopmentaldisease severityfunctional declinefunctional status declinegene defectgenome mutationlacunar infarctslacunar strokelife courselife-style factorlifestyle factorsmicrovascular complicationsmicrovascular diseasemini strokemini-strokemodifiable lifestyle factorsmotor abilitymutant allelemutation carrierneural imagingneuro-imagingneurofilamentneuroimagingneurological imagingneuropsychologicnovelorphan disorderpathophysiologyphenotypic biomarkerphenotypic markerpre-clinical studypreclinical studyprimary outcomerate of changeresponsesexsmall vessel diseasesocial rolestrokedstrokessubstantia albatrial readinessvascularvascular cognitive impairment and dementiavascular contribution to impairment or dementiavascular contributions in dementiavascular contributions to cognition/dementiavascular contributions to cognitive decline and dementiavascular contributions to cognitive impairment and dementiavascular contributions to dementiavascular related dementiawhite matterwhite matter change
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PROJECT SUMMARY
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is
the most common monogenic cause of stroke and vascular contributions to cognitive impairment and dementia
(VCID). In this project, we will study CADASIL patients with NOTCH3 mutations. Preclinical studies have
indicated that…
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