grant
Cerebellar-striatal circuits for control of dopamine activity and food intake
Organization SCINTILLON INSTITUTE FOR PHOTOBIOLOGYLocation SAN DIEGO, UNITED STATESPosted 16 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AffectiveAnatomic SitesAnatomic structuresAnatomyAnimalsAnteriorAppetiteAppetite DisorderBody WeightBrainBrain Nervous SystemBrain imagingCalciumCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCerebellar NucleiCerebellumConsumptionCorpus StriatumCorpus striatum structureD(2) Dopamine Receptor GeneD2DRD2DR GeneD2RD2R GeneDRD2DRD2 geneDataDesire for foodDevelopmentDopamineDopamine Receptor D2 GeneDysfunctionEatingEating DisordersEncephalonFoodFood IntakeFunctional disorderGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGenetic TranscriptionGoalsH2O syndromeHumanHydroxytyramineIndividualIntracellular Communication and SignalingLabhart-Willi SyndromeLabhart-Willi-Prader-Fanconi SyndromeLateralLeannessLinkMediatingMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureModern ManMolecularMolecular FingerprintingMolecular ProfilingMonitorMotivationMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNucleusNutrientObese MiceObesityOutputPathway interactionsPatientsPhasePhenocopyPhysiologicPhysiologicalPhysiopathologyPopulationPrader-Labhart-Willi (PLW) syndromePrader-Labhart-Willi syndromePrader-Labhart-Willi-Fanconi syndromePrader-Willi SyndromePrader-Willi syndrome (PWS)Psychological reinforcementPublishingRNA ExpressionRabiesReinforcementResearchRewardsRodentRodentiaRodents MammalsSatiationSignal TransductionSignal Transduction SystemsSignalingSingle cell seqSingle-Nucleus SequencingSourceStomachStriate BodyStriatumSubstantia NigraSubstantia nigra structureSystemTestingThinnessTranscriptTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionVentral Tegmental AreaViralWeight maintenance regimenWorkadiposityanalyze gene expressionaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbrain visualizationcardiorespiratory syndrome of obesity in childcell typeconditioned place preferencecorpulencedetection of nutrientdevelopmentaldiet-associated obesitydiet-induced obesitydiet-related obesityeat lesseating cuesexperimentexperimental researchexperimental studyexperimentsexpression subtypesfeedingfood cuesgastricgene expression analysisgene expression assayglia signalingglial signalinghunger cueshypogenital dystrophy with diabetic tendency syndromehypotonia-hypogonadism-obesity syndromehypotonia-hypopigmentia-hypogonadism-obesity (HHHO) syndromehypotonia-hypopigmentia-hypogonadism-obesity syndromehypotonia-obesity-hypogonadism-mental retardation syndromelyssametabolic ratemolecular profilemolecular signaturemolecular sub-typesmolecular subsetsmolecular subtypesnerve signalingneuralneural circuitneural circuitryneural imagingneural patterningneural signalingneuro-imagingneurocircuitryneuroimagingneurological imagingneuronalneuronal signalingneurotransmissionnovelnutrient sensingob/ob mousepathophysiologypathwayperception of nutrientspharmacologicplace conditioningreduced eatingreduced food intakeresponsereward processingsNuc-Seqsatietysingle cell next generation sequencingsingle cell sequencingsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqstriatalsynaptic circuitsynaptic circuitrytooltranscriptional profilingventral tegmentumweight controlweight management
Description preview
Project Summary
Recently, we identified the cerebellum as a novel satiation center in the brain. Yet, little is known about the
pathways and circuit mechanisms through which the cerebellum regulates food intake. The major research goal
of this proposal is to define cerebellar à striatal circuits that regulate food intake and better understand the…
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