grant
Cerebellar-Cortical Circuitry and Treatment Response in Early Psychosis
Organization FEINSTEIN INSTITUTE FOR MEDICAL RESEARCHLocation MANHASSET, UNITED STATESPosted 15 Jun 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AnisotropyAntipsychotic AgentsAntipsychotic DrugsAntipsychoticsAreaBiological MarkersBrainBrain Nervous SystemCerebellar CortexCerebellumCerebral cortexClinicalDataData CollectionData SetDelusionsDiseaseDisorderDrugsEncephalonEvaluationFiberFriendsFunctional MRIFunctional Magnetic Resonance ImagingFutureGoalsHallucinationsHumanIndividualInvestigationMRI ScansMachine LearningMagnetic Resonance Imaging ScanMajor TranquilizersMajor Tranquilizing AgentsMeasuresMedicationModelingModern ManMultimodal ImagingNatureNeuroleptic AgentsNeuroleptic DrugsNeurolepticsOutcomePathogenesisPatientsPerformancePharmaceutical PreparationsPhysiciansPrediction of Response to TherapyPredictive ValuePrognostic MarkerPropertyPsychiatryPsychosesPsychotic DisordersPublishingQOLQuality of lifeRestRoleSamplingStimulusSystemTechniquesTestingTrainingTranslatingTreatment EfficacyUpdateValidationWorkbio-markersbiologic markerbiomarkerbiomarker validationchronic mental illnessclinical translationclinically translatablecognitive systemcognitive taskcomputer based predictionconnectomeconnectome based predictive modelingdeep learningdeep learning methoddeep learning strategydrug/agentearly psychosisfMRIfeature selectionfirst episode psychosisimprovedineffective therapiesineffective treatmentintervention efficacymachine based learningmarker validationmulti-modal imagingmulti-modalitymulti-modality imagingmultimodalitymultimodality imagingoptimal therapiesoptimal treatmentspersistent mental illnesspredict therapeutic responsepredict therapy responsepredictive biological markerpredictive biomarkerspredictive markerpredictive modelingpredictive molecular biomarkerprognostic biomarkerprognostic indicatorpsychoticpsychotic illnesspsychotic symptomsresponseresponse to therapyresponse to treatmentsensory cortexserious mental disorderserious mental illnesssevere mental disordersevere mental illnesssocial rolesubstantia albatherapeutic efficacytherapeutic responsetherapy efficacytherapy predictiontherapy responsetraittreatment planningtreatment predictiontreatment responsetreatment response predictiontreatment responsivenessvalidationswhite matter
Description preview
Abstract
Identifying circuitry-based biomarkers of treatment response to antipsychotic medication is critically important
for precision psychiatry, which may help physicians make optimal treatment plans at the early stage, reducing
the course of ineffective treatment and benefiting long-term life quality of patients. Using functional magnetic…
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