grant
Cellular/Molecular Mechanisms of Respiratory Neuronal Chemosensitivity
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 May 2011Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Acid-Base BalanceAcid-Base EquilibriumAcidsAcuteAddressAfferent NeuronsAirAnimalsArousalArteriesAssayBehavioralBioassayBiological AssayBirthBlood gasBody TissuesBrainBrain Nervous SystemBrain StemBrainstemBreathingCOPDCell BodyCell NucleusCellsChemoreceptorsChronicChronic DiseaseChronic IllnessChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseClassificationClinicalConsciousConsciousnessCot DeathCoupledCrib DeathCustomDNA Molecular BiologyDNA mutationDataDepressed moodDetectionDevelopmentDiseaseDisorderDysfunctionElectrophysiologyElectrophysiology (science)ElementsEncephalonFunctional disorderG Protein Coupled Receptor 4G Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGPR4GPR4 geneGene ExpressionGeneticGenetic ChangeGenetic ModelsGenetic defectGenetic mutationH+ elementHydrogen IonsHypercapnic respiratory failureHypoventilationIn VitroK channelKO miceKnock-outKnock-out MiceKnockoutKnockout MiceMediatingMiceMice MammalsModelingMolecularMolecular AnalysisMolecular BiologyMolecular TargetMonitorMurineMusMutationNeonatalNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropeptidesNeurophysiology / ElectrophysiologyNucleusNull MousePACAPParturitionPathologicPathologyPhenotypePhotometryPhysiologicPhysiologicalPhysiologyPhysiopathologyPickwickian SyndromePlethysmographyPopulationPotassium ChannelPotassium Ion ChannelsProtonsProxyReflexReflex actionRespirationRespiration DisordersRespiratory AspirationRespiratory DisorderRespiratory InspirationSIDSSensorySensory NeuronsSpecific qualifier valueSpecifiedSudden Infant DeathSudden Unexpected Infant DeathSudden infant death syndromeSyndromeSystemSystematicsTestingTissuesTransgenesWorkbasebasesbreathing disordercellular targetingchronic disorderchronic obstructive pulmonary disordercongenital central hypoventilation syndromecustomsdepresseddetectordevelopmentaldisease modeldisorder modelelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfunctional outcomesgenome mutationin vivoinspirationloss of functionmouse geneticsmouse modelmurine modelneonatal periodneural adaptationneuroadaptationneuronalneuronal excitabilitynovelobesity hypoventilation syndromeoptogeneticspatch clamppathophysiologypituitary adenylate cyclase activating peptidepituitary adenylate cyclase activating polypeptidepostnatalrespiratoryrespiratory dysfunctionrespiratory mechanismresponsesadnessscRNA sequencingscRNA-seqsensorsensory mechanismsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingtransgene
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PROJECT SUMMARY
An interoceptive system within the CNS monitors levels of CO2 (or its proxy, H+) and regulates respiratory drive for
rapid homeostatic control of blood gases and systemic acid-base balance; dysfunction of this central respiratory chem-
oreception is cause or consequence of numerous hypoventilation syndromes. Despite recognition of…
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