grant
Cellular mechanisms of macrophage activation syndrome
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 17 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years oldAdult-Onset Still's DiseaseAgonistAutomobile DrivingAwardBioinformaticsBiologyBiopsy SampleBiopsy SpecimenBlast TransformationBlastogenesisBlood monocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBone marrow biopsyCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell Surface ReceptorsCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsChildChild CareChild YouthChildren (0-21)Children's HospitalCirculationCollaborationsComplexComplicationDataData AnalysesData AnalysisDevelopmentDevelopment PlansDevelopment and ResearchDiagnosisDiseaseDisorderEndosomesEnvironmentExhibitsExpression SignatureFoundationsGene ExpressionGene Expression ProfileGene TranscriptionGenetic TranscriptionGoalsHemophagocytic LymphohistiocytosesHumanIFNIFN-GammaIFN-Gamma-Inducing Factor GeneIFN-gIFN-gamma-Inducing FactorIFN-γIFNGIFNγIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-15IL-18IL-18 GeneIL-1gIL-1g GeneIL15IL15 ProteinIL18IL18 ProteinIL18 geneIL1F4IL1F4 GeneImmuneImmune InterferonImmune responseImmunesImmunologyInfectionInflammationInflammatoryInflammatory ResponseInterferon GammaInterferon Type IInterferon Type IIInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterferonsInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-15Interleukin-15 PrecursorInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneIntracellular Communication and SignalingJuvenile-Onset Still's DiseaseKnowledgeLaboratoriesLifeLocationLupusLupus Erythematosus DisseminatusLymphatic cellLymphoblast TransformationLymphocyteLymphocyte ActivationLymphocyte StimulationLymphocyte TransformationLymphocyticMGC12320MGC12320 GeneMGC9721Macrophage activation syndromeMalignant NeoplasmsMalignant TumorMarrowMarrow monocyteMediatingMentorshipModern ManMolecularMusculoskeletal Pain DisorderMyeloid CellsNucleic AcidsPathogenesisPathogenicityPatientsPediatric HospitalsPeripheralPhagocytesPhagocytic CellPhenotypePhysiciansPlayPositionPositioning AttributePreparationProductionPuericultureR & DR&DRNA ExpressionReceptor ProteinReceptosomesResearchResearch InstituteResearch ResourcesResourcesRheumatic DiseasesRheumatismRheumatologic DiseasesRheumatologic DisorderRoleSLESamplingScientistSecondary toShapesSignal TransductionSignal Transduction SystemsSignalingSiteSourceStill's diseaseSubcellular ProcessSyndromeSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT cell responseT-Cell ActivationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTLR7TLR7 geneTLR8TLR8 geneTechniquesTestingTissuesToll-Like Receptor 7Toll-Like Receptor 8TrainingTranscriptionTranslational ResearchTranslational ScienceUniversitiesUpregulationViralWashingtonWorkactivate T cellsamebocytebiological signal transductionbonecareercareer developmentcytokinecytopeniadata interpretationdevelopmentaldisseminated lupus erythematosusdrivinggene expression patterngene expression signaturehost responseimmune system responseimmunoresponseimprovedinsightkidslFN-Gammalymph cellmalignancymonocytemouse modelmurine modelneoplasm/cancernovelpreparationsreceptorresearch and developmentresponserheumatologistscRNA sequencingscRNA-seqsensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynergismsystemic juvenile idiopathic arthritissystemic lupus erythematosissystemic onset juvenile idiopathic arthritistherapeutic targetthymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptomicstranslation researchtranslational immunologytranslational investigationyoungster
Description preview
ABSTRACT
Macrophage activation syndrome (MAS) or secondary hemophagocytic lymphohistiocytosis (sHLH) is a
dysfunctional, potentially fatal, hyperinflammatory response that is characterized by abnormal activation of
lymphocytes and phagocytes leading to an overproduction of inflammatory cytokines and damage of host
tissues. In rheumatic disease,…
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