grant
Cellular and molecular mechanisms of IL-17A in the pathogenesis of psoriatic arthritis
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026(TNF)-αAcanthosisAdoptive TransferAnimal ModelAnimal Models and Related StudiesAntibodiesArthritisAutoimmune StatusAutoimmunityBindingBioavailabilityBiological AgentBiological AvailabilityBiological ProductsBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesBone MarrowBone Marrow GraftingBone Marrow Reticuloendothelial SystemBone Marrow TransplantBone Marrow TransplantationCD115CD115 GeneCD11bCR3ACSF1RCSF1R geneCSFMRCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCXCL1CXCL1 geneCachectinCell BodyCell Communication and SignalingCell SignalingCellsChronicChronologyCirculationClinicalClinical Treatment MoabColony Stimulating Factor 1 Receptor GeneComplementComplement ProteinsCutaneousCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDetectionDevelopmentDiagnosisDiseaseDisease MarkerDisorderDorsalEventExperimental ModelsFeedbackFibrocartilagesFinger NailFingernailFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGM-CSFGRO1GROAGene TransferGranulocyte-Macrophage Colony-Stimulating FactorHistamine-Producing Cell-Stimulating FactorHistopathologyHyperplasiaHyperplasticIL 17 Signaling PathwayIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 Signaling PathwayIL17 geneIL17AIL17A GeneIRF4IRF4 geneITGAMITGAM geneImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmunesImmunityImmunofluorescenceImmunofluorescence ImmunologicImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfectionInflammationInflammatoryInflammatory ArthritisInterferon Regulatory Factor 4Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17InterleukinsIntracellular Communication and SignalingJointsKO miceKnock-out MiceKnockout MiceLSIRF ProteinLightLinkLymphatic cellLymphocyteLymphocyticMAC1AMGSAMO1AMacrophage-Derived TNFMapsMarrow NeutrophilMarrow TransplantationMethodologyMiceMice MammalsMicroscopyMolecularMolecular FingerprintingMolecular InteractionMolecular ProfilingMolecular TargetMolgramostinMonoclonal AntibodiesMonocyte-Derived TNFMultiple Myeloma Oncogene 1MurineMusMyelogenousMyeloidMyelopoiesisNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteNull MouseOrganOsteoclastsOutcomeParakeratosisPathogenesisPathogenicityPathologicPathologyPathway interactionsPatientsPenetrancePhotoradiationPhysiologicPhysiologic AvailabilityPhysiologicalPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPsoriasisPsoriasis ArthropathicaPsoriatic ArthritisPublishingRNA SeqRNA sequencingRNAseqReporterRiskRoleSCYB1SafetySignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSkin developmentStructure of nail of fingerSynovitisTC-GM-CSFTNFTNF ATNF AlphaTNF Receptor-Associated Factor 6 GeneTNF geneTNF-αTNFATNFαTRAF2TRAF2 geneTRAF6TRAF6 geneTRAP3TechnologyTherapeuticTherapeutic InterventionTissuesTransgenic MiceTumor Necrosis FactorTumor Necrosis Factor-alphaTumor-Cell Human GM Colony-Stimulating FactorWorkantagonismantagonistarthriticbiological signal transductionbiologicsbiomarker identificationbiopharmaceuticalbiotherapeutic agentbone erosionbone lossc-FMSc-fms Genesc-fms Proto-Oncogenescancer typecell typecomplementationcytokinedevelopmentaldosageenthesitisexperimentexperimental researchexperimental studyexperimentsfibrocartilaginousflow cytophotometryidentification of biomarkersidentification of new biomarkersimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedin vivoinflamed synovial tissueinflamed synoviuminflammation markerinflammatory markerinhibitorinnovateinnovationinnovativeintervention therapyjoint functionlymph cellmAbsmRNA Expressionmarker identificationmodel of animalmolecular profilemolecular signaturemonoclonal Absmouse modelmurine modelnail psoriasisneutrophilnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachosteoclastogenesispathwaypatient prognosispatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespleiotropic effectpleiotropismpleiotropypreventpreventingpromoterpromotorpsoriasiformpsoriaticpsoriatic nailscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskin organogenesissocial rolesuccesssynergismsynovial inflammationtooltranscriptome sequencingtranscriptomic sequencing
Description preview
Project Summary/Abstract
Psoriatic arthritis is a chronic and progressive inflammatory arthritis closely linked with psoriasis.
Blockade of the IL-17 signaling pathway shows impressive efficacy and excellent safety for
treatment of psoriasis but less so for PsA. Tissue penetrance limits the bioavailability of
monoclonal antibodies to the joint and…
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