grant
Cellular and molecular architecture of granulomas in human tuberculous lymphadenitis
NIHUS FederalResearch GrantFY2025519 proteinAcuteAffectAntigensArchitectureBacillusBacteriaBiological MarkersBiopsyBody TissuesCausalityCell-Mediated Lympholytic CellsChronicChronic DiseaseChronic IllnessClinicalCollaborationsCollectionCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesD2S69EDataDiagnosisDiagnosticDiseaseDisorderEngineering / ArchitectureEnsureEtiologyGNLYGene ExpressionGenesGranulomaGranulomatous LesionHansen's DiseaseHealthHealth Care SystemsHistologicHistologicallyHost DefenseHost Defense MechanismHumanIFNImmuneImmune MarkersImmune responseImmunesImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologic MarkersImmunosuppressed HostIndividualInfectionInfection ControlInflammationInflammatory ResponseInterferonsInvadedLAG-2LAG2LeprosyLigandsLocationLung TBLung TuberculosisLymph Node Reticuloendothelial SystemLymph Node TuberculosisLymph node properLymphatic cellLymphatic nodesLymphocyteLymphocyticM bovisM tbM tuberculosisM tuberculosis infectionM. bovisM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMacrophage ActivationMapsMeasuresMediatorMicroscopyModalityModern ManMolecularMycobacterial InfectionMycobacterium InfectionsMycobacterium bovisMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMycobacterium tuberculosis var. bovisMφNKG5OrganPathologicPathway interactionsPatient CarePatient Care DeliveryPatientsPulmonary TBPulmonary TuberculosisPyrazinamidePyrazinecarboxamideRadiographyResearch SpecimenResearch TrainingResistanceRoentgenographyScientistSiteSpatial DistributionSpecimenT cell responseT-CellsT-LymphocyteT-lymphocyte activation gene 519TB granulomaTB infectionTLA519Technology TransferTestingTherapeuticTissuesTuberculosisTuberculous LymphadenitisTunisiaanti-microbialanti-microbial peptideantimicrobialbio-markersbiologic markerbiomarkerbiomarker identificationbiosignaturecare for patientscare of patientscaring for patientscausationcell typechronic disorderclinical carecytokinedata integrationdisease causationdisseminated TBdisseminated tuberculosisgranulysinhost responseidentification of biomarkersidentification of new biomarkersimmune system responseimmune-based biomarkersimmunogenimmunological biomarkersimmunological markersimmunoresponseimmunosuppressed patientimprovedinfection due to Mycobacterium tuberculosisinsightkiller T celllymph celllymph glandlymph nodeslymphnodesmarker identificationmicrobicidalmicrobicidemolecular biomarkermolecular markermtbmycobacterialpathogenpathwayperipheral bloodpulmonaryradiological imagingresistantresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingtechnology trainingthymus derived lymphocytetranscriptomicstuberculosis granulomatuberculosis infectiontuberculous spondyloarthropathy
Description preview
ABSTRACT
Tuberculous lymphadenitis (TBL) is the most frequent form of extrapulmonary of TB affecting approximately
2000 individuals in Tunisia annually, such that the disease is a clinical burden on the Tunisian health care
system. Since the occurrence of concomitant pulmonary TB in TBL patients is infrequent, and bacilli are rarely
detected by…
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