grant
Cell-type specific excitability and molecular mechanisms of opioid seeking
Organization LOUISIANA STATE UNIV A&M COL BATON ROUGELocation BATON ROUGE, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AcuteAnimalsAreaBehaviorBehavioralBreedingCRE RecombinaseCell BodyCellsCholine AcetylaseCholine AcetyltransferaseCholine O-AcetyltransferaseCommon Rat StrainsConnector NeuronCuesDiacetylmorphineDiamorphineDisparateDopamineDrugsElectrophysiologyElectrophysiology (science)Enterobacteria phage P1 Cre recombinaseExtinctionGoalsHeroinHydroxytyramineIndividualIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionInvestigationInvestigatorsKnowledgeLabelLinkLiteratureMedicationMembrane PotentialsMethodsMolecularNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNucleus AccumbensOpiatesOpioidParvalbuminsPatientsPharmaceutical PreparationsPopulationPositionPositioning AttributePublicationsRatRat TransgeneRats MammalsRattusReceptor ProteinRelapseResearch PersonnelResearchersRestResting PotentialsRoleSalineSaline SolutionScientific PublicationSelf AdministeredSelf AdministrationSliceSodium ChannelSodium Ion ChannelsStressSubstance Use DisorderTestingTherapeuticTransmembrane PotentialsViralViral VectorVirusaddictionaddictive disorderbacteriophage P1 recombinase Crecell typedifferential expressiondifferentially expresseddrug cravingdrug rewarddrug/agentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsinnovateinnovationinnovativeknock-downknockdownneural adaptationneuroadaptationneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetopiate consumptionopiate deathsopiate drug useopiate exposureopiate intakeopiate mortalityopiate useopioid consumptionopioid deathsopioid drug useopioid exposureopioid intakeopioid mortalityopioid overdose deathopioid related deathopioid usepharmacologicpromoterpromotorreceptorshRNAshort hairpin RNAsmall hairpin RNAsocial rolesubstance use and disordertooltranscriptional differences
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Project Summary / Abstract
Substance use disorders (SUDs) afflict 1 in 10 individuals, and opioid overdose deaths have quintupled over the
last 20 years. There is a critical need to develop interventions that can reverse or block opioid-induced changes
that can reduce relapse in patients with SUD. Our long-term goal is to better understand how…
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