grant
Cell-type specific evaluation of globus pallidus pars externa as a translational target to improve sleep and arousal
Organization VA BOSTON HEALTH CARE SYSTEMLocation BOSTON, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
VANIHUS FederalResearch GrantFY2026AffectAlgorithmsAmentiaArousalBasal GangliaBasal NucleiBasal Transcription FactorBasal transcription factor genesBilateralBotanical medicineBrainBrain Nervous SystemBrain TraumaCRE RecombinaseCalcium-Binding ProteinsCell NucleusClozapineCognition TherapyCognitive PsychotherapyCognitive TherapyCognitive treatmentDarknessDataDeep Brain StimulationDegenerative Neurologic DisordersDementiaDiseaseDisorderDoseDrug TherapyDrugsEEGElectrical Stimulation of the BrainElectroencephalogramElectroencephalographyEncephalonEnhancersEnterobacteria phage P1 Cre recombinaseEvaluationFrequenciesG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGene ModifiedGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGlobus PallidusGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHabitsHourHumanInfusionInfusion proceduresInjectionsInsomniaInsomnia DisorderIon ChannelIon PumpsIonic ChannelsK channelLaser ElectromagneticLaser RadiationLasersLightLinkMajor Depressive DisorderMediatingMedicationMedicinal PlantsMembrane ChannelsMental DepressionMethodologyMethodsMiceMice MammalsMicrodialysisModelingModern ManMurineMusNREMNatural CompoundNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNucleusOpsinOxidesPTSDParalysis AgitansParkinsonParkinson DiseasePars ExternaParvalbuminsPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyPhenotypePhotoradiationPhytomedicinesPhytotherapeuticsPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPotassium ChannelPotassium Ion ChannelsPrimary InsomniaPrimary ParkinsonismProteinsProtocolProtocols documentationReceptor ProteinRecombinant adeno-associated virusRecombinant adeno-associated virus (rAAV)ResearchResearch PriorityRod-OpsinRoleRosemaryRosmarinus officinalisSchizophreniaSchizophrenic DisordersSleepSleep disturbancesSleeplessnessStaining methodStainsStructureSubstance abuse problemSubstantia NigraSubstantia nigra structureSuicideTechniquesTestingTherapeutic AgentsTimeTranscription Factor Proto-OncogeneTranscription factor genesTranslationsTraumatic Brain InjuryVeteransViralViral VectorWild Type Mouseaberrant sleepabuse of substancesalertnessalternative treatmentbacteriophage P1 recombinase Crecarnosic acidcell typecircadianclinical depressioncognitive behavior interventioncognitive behavior modificationcognitive behavior therapycognitive behavioral interventioncognitive behavioral modificationcognitive behavioral therapycognitive behavioral treatmentdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia praecoxdepressiondisrupted sleepdisturbed sleepdrug interventiondrug treatmentdrug/agentexperimentexperimental researchexperimental studyexperimentsfatal attemptfatal suicidegene modificationgenetically modifiedimpaired sleepimprovement on sleepinfusionsinnovateinnovationinnovativeintent to dieirregular sleepmajor depressionmajor depression disordermemory consolidationnaturally occurring compoundneural controlneural degenerationneural regulationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuromodulationneuromodulatoryneuronalneuronal degenerationneuroregulationnew approachesnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnovelnovel approachesnovel strategiesnovel strategyopiate use disorderopioid use disorderoptogeneticspallidumpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost-trauma stress disorderposttrauma stress disorderpre-clinical studypreclinical studyrAAVreceptorrecombinant AAVrelapse riskretrograde transportsalvinschizophrenicsleep abnormalitiessleep amountsleep disruptionsleep durationsleep dysregulationsleep episodesleep improvementsleep intervalsleep lengthsleep periodsleep quantitysleep spindlesleep timesleep/wake disruptionsleep/wake disturbancesocial rolesubstance abusesuicidal risksuicide risksuicidestime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtranscription factortranslationtranslational applicationstraumatic brain damagetraumatic neurosisvectorwildtype mouse
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Description preview
Significance to VA. Disrupted sleep occurs in many conditions common in Veterans, including VA
research priorities such as post-traumatic stress disorder (PTSD), substance abuse, major depression and
neurodegenerative disorders. Insomnia is associated with an increased risk for suicide and increases the risk
for relapse in opioid use disorder.…
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