grant
Cell-Type Selective Transcriptional and Mitochondrial Control of Drug Seeking
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 15 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAbstinenceAcetyl CoAAcetyl Coenzyme AActivities of Daily LivingActivities of everyday lifeAmmon HornAreaAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBiologic ModelsBiological ModelsBody TissuesBrainBrain Nervous SystemBrain regionCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR interferenceCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-dCas9-mediated repressionCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/dCas9 activationCRISPR/dCas9 interferenceCRISPR/dCas9-based transcriptional activationCRISPR/dCas9-mediated transcriptional inhibitionCRISPRaCRISPRiChromatinChronicClustered Regularly Interspaced Short Palindromic Repeats interferenceCocaineComplexCornu AmmonisCorpus StriatumCorpus striatum structureCuesD2 receptorDRD2 ReceptorDataDendritesDopamine D2 ReceptorDrug ControlsDrug usageDrugsElectron TransportElectronic cigaretteElectrophysiologyElectrophysiology (science)EncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenomeGuide RNAHDACHDAC AgentHDAC ProteinsHDAC inhibitorHippocampusHistone DeacetylaseHistone Deacetylase InhibitorHistone deacetylase inhibitionIndividualIntakeIntravenousLabelLearningLengthLinkMeasuresMediatingMedicationMetabolicMiceMice MammalsMitochondriaModel SystemModificationMolecularMolecular TargetMorphologyMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNicotineNicotine Use DisorderNucleus AccumbensPathway interactionsPharmaceutical PreparationsPopulationProductionPropertyPsychological reinforcementRNA ExpressionRegulationRegulator GenesReinforcementRelapseRespirationRewardsS-acetate Coenzyme ASelf AdministeredSelf AdministrationSignal PathwaySingle-Nucleus SequencingSpecificitySpinal ColumnSpineStriate BodyStriatumSubstance Use DisorderTechniquesTestingTherapeuticTissuesTobaccoTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional Regulatory ElementsTransgenic MiceTranslatingVenousVertebral columnViral VectorWorkactivating CRISPR technologyanalyze gene expressionassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbackbonebrain tissuecease smokingcell typechromatin modificationco-morbidco-morbiditycocaine seekingcomorbiditycravingdaily living functiondaily living functionalitydensitydrivingdrug relapsedrug rewarddrug seeking behaviordrug usedrug/agente-cige-cigaretteecigecigaretteelectron transferelectrophysiologicalepigeneticallyepigenomefunctional abilityfunctional capacitygRNAgene expression analysisgene expression assaygenetic trans acting elementhippocampalhistone modificationimprovedinsightmitochondrialmouse modelmultiomicsmultiple omicsmultiple substance usemultisubstance usemurine modelneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnicotine consumptionnicotine rewardnicotine seekingnicotine seeking behaviornicotine self-administrationnicotine usenovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpanomicspathwaypoly substance usepolysubstance useprogramsquit smokingregulatory generepressing CRISPR-dCas9 systemrespiratoryrespiratory mechanismresponsesNuc-Seqselective expressionselectively expressedsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqskillssmoking cessationsnRNA sequencingsnRNA-seqstop smokingstriatalsubstance usesubstance use and disordersubstance usingtraining opportunitytrans acting elementtranscription factortranscriptional profiling
Description preview
Substance use disorders comprise chronic cycles of drug use, abstinence, and relapse driven by drug-induced
transcriptional and circuit adaptations in the brain. Despite consistent evidence that epigenetic chromatin
modifications drive these long-term neuronal adaptations, successful druggable treatment targets have not
emerged, and further…
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