grant
Cell surface proteolysis in development, tissue repair, and malignancy
Organization NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCHLocation UNITED STATES
NIHUS FederalResearch GrantFY20255-FU5-Fluracil5FUAcanthosisAccelerationAfibrinogenemiaAfter CareAfter-TreatmentAftercareAnemiaAssayAutoregulationBacteriaBioassayBiochemistryBiological AssayBiological ChemistryBiologyBleedingBlood Coagulation Factor IBlood Coagulation Factor OneBlood Coagulation Factor XIIIBlood Factor OneBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBuccal MucosaC albicansC. albicansC.albicansCR3CR3 ReceptorCancersCandida albicansCell surfaceCell-Extracellular MatrixChemotherapy ProtocolChemotherapy RegimenChemotherapy-Oncologic ProcedureCoagulation Factor ICoagulation Factor OneCoagulation Factor XIIICollaborationsColoring AgentsCombination Chemotherapy RegimenComplement 3 ReceptorComplicationCongenic MiceCongenital afibrinogenemiaCongenital hypofibrinogenemiaDepositDepositionDevelopmentDoseDrugsDyesEC 3.4.21.7ECMEnzyme PrecursorsEpithelial CellsEpitheliumEsteroproteasesExtracellular MatrixFactor IFactor I DeficiencyFactor OneFactor XIIIFactor XIII TransamidaseFailureFamilyFibrinFibrin Stabilizing FactorFibrinaseFibrinogenFibrinogen DeficiencyFluoro UracilFluorouracilFluoruracilFluouracilFutureGene ClusterGenesGeneticHematopoieticHemorrhageHemostatic AgentsHemostaticsHereditary factor I deficiency diseaseHereditary hypofibrinogenemiaHistologicHistologicallyHomeostasisHyperkeratosisImmobilizationImmune infiltratesImmunityImmunologic SubtypingImmunophenotypingImpairmentIndividualInfectionInflammatoryIntegrin alpha-M beta-2Integrin alphaMbeta2Laki-Lorand FactorLifeLiposomalLiposomesLiverMac 1Mac-1 Adhesive ReceptorMac-1 AntigenMac-1 ReceptorMacrophage-1 AntigenMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMarrow NeutrophilMedicationMembraneMessenger RNAMiceMice MammalsMissionMo1 Antigen ReceptorMo1 Glycoprotein ReceptorMouse StrainsMouth MucosaMurineMusMyelogenousMyeloidMyeloid CellsMyelosuppressionNIAIDNational Institute of Allergy and Infectious DiseaseNatural regenerationNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Polyadenylated RNAOperative ProceduresOperative Surgical ProceduresOral MoniliasisOral MucosaOral PathologyOral candidiasisOral mucous membrane structurePalatePathogenesisPathologyPathway interactionsPenetrationPeptidasesPeptide HydrolasesPharmaceutical PreparationsPhysiological HomeostasisPlasminogenPolymersPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPredispositionProenzymesProfibrinolysinProtease GeneProteasesProtein CleavageProteinasesProteinsProteolysisProteolytic EnzymesQuimioterapiaRNARNA Gene ProductsRadiationRecoveryRegenerationRibonucleic AcidRoleSerine EndopeptidasesSerine ProteaseSerine Protein HydrolasesSerine ProteinasesShort interfering RNASmall Interfering RNASurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTherapeuticThrombaseThrombinThrushTissuesTolonium chlorideToluidine BlueTongueTranscriptUlcerUlcerationWisconsinZymogensblood losscancer chemotherapychemotherapycrosslinkdefined contributiondevelopmentaldrug/agentfibrinogenasegene nullhemopoietichepatic body systemhepatic organ systemhuman RNA sequencinghuman RNA-seqimmune cell infiltrateinjury to tissuemRNAmalignancymedical collegemedical schoolsmembermembrane structuremouth candidamutantmycotic stomatitisneoplasm/cancerneutrophilnull mutationoral candidaoral cavity epitheliumoral epitheliaoral epitheliumoral fungaloral immunityoral mucosaeoral mucosaloral tissueorthopedic freezingpathwaypolymerpolymericpolymerizationpost treatmentrecruitregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresponsescRNA sequencingscRNA-seqschool of medicinesiRNAsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestemsurgerytissue injurytissue regenerationtissue regrowthtissue renewaltissue repairtissue specific regenerationvascularαMβ2
Description preview
General Mission Statement:
The overall aim of this project is to understand the biochemistry, biology, and pathology of cell surface-associated proteolysis, with an emphasis on defining the contribution of proteolytic pathways to the development, homeostasis, regeneration, and pathology of oral tissues.
Ongoing efforts and future plans:
A…
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