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Cell Cycle Control Of Arterial-Venous Specification Within the Developing Embryo
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2026 β οΈ
NIHUS FederalResearch GrantFY2025ArteriesAutoregulationBMP4BP homeostasisBP regulationBloodBlood PressureBlood Reticuloendothelial SystemBlood VesselsBlood capillariesBlood flowBody TissuesBone-Derived Transforming Growth FactorCancersCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell CycleCell Cycle ControlCell Cycle GenesCell Cycle RegulationCell DifferentiationCell Differentiation processCell Division CycleCell Division Cycle GenesCell LineCell SignalingCellLineCellsCharacteristicsClinical TreatmentDataDefectDevelopmentDiseaseDisorderDorsalEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic ArteryEmbryonic DevelopmentEmbryonic arterial structureEndothelial CellsEndotheliumExhibitsFluorescence Activated Cell Sorting FractionationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsFutureGasesGene ExpressionGenesHeart VascularHomeostasisHumanImmuneImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIntracellular Communication and SignalingLigandsMalignant NeoplasmsMalignant TumorMediatingMiceMice MammalsMilk Growth FactorModelingModern ManMurineMusNutrientPathologicPathologyPhysiological HomeostasisPlatelet Transforming Growth FactorProcessRNA SeqRNA sequencingRNAseqReceptor ProteinRegenerative MedicineRegulationReporterRetinaRoleSignal TransductionSignal Transduction SystemsSignalingSortingSpecific qualifier valueSpecifiedStrains Cell LinesTGF BTGF-betaTGF-Ξ²TGFbetaTGFΞ²TestingTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTumor AngiogenesisUbiquitilationUbiquitinationUbiquitinoylationUpregulationVascular remodelingVascularizationVeinsVenousVenous AngiomaVenous MalformationWorkangiogenesisbiological signal transductionblood pressure homeostasisblood pressure regulationcapillarycardiovascular disordercdc Genescellular differentiationcerebral cavernous malformationscirculatory systemclinical interventionclinical therapycultured cell linedevelopmentalengineered vascular tissueengineered vascularized tissuegain of functionglobal gene expressionglobal transcription profilehuman progenitorhuman stem cellsimprovedin vivoinhibitorinjuredinsightloss of functionmalformationmalignancyneoplasm/cancerneuron developmentneuronal developmentnotchnotch proteinnotch receptorsnovelpostnatalprogenitorreceptorregeneration based therapyregeneration therapyregenerative therapeuticsregenerative therapyregulate BPregulate blood pressureretinal angiogenesisrevascularizationscRNA sequencingscRNA-seqshear stresssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletraffickingtranscriptometranscriptome sequencingtranscriptomic sequencingtrial regimentrial treatmenttumorubiquinationubiquitin conjugationvascularvascular tissue engineeringvenulewasting
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Project Summary:
The blood vascular circulatory system is composed of arterial, venous, and capillary vessels, which work
together to facilitate the efficient exchange of gasses, nutrients, and waste from all tissues, while regulating blood
pressure and distribution of immune cells. The endothelial cells that line these vessels must acquireβ¦
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