grant
Cell cycle and checkpoint variations in development and disease
Organization TRUSTEES OF INDIANA UNIVERSITYLocation BLOOMINGTON, UNITED STATESPosted 5 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAffectAntioncogene Protein p53ApoptoticBiologic ModelsBiological ModelsBody TissuesCancer InductionCancer TreatmentCancersCell BodyCell Culture TechniquesCell CycleCell Cycle ControlCell Cycle RegulationCell Division CycleCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCellular Tumor Antigen P53ClinicCommentCommentaryCompetenceDNA DamageDNA InjuryDevelopmentDevelopmental TherapeuticsDevelopmental Therapeutics ProgramDevelopmental TherapyDiagnosisDiseaseDisorderDrosophilaDrosophila genusDrosophila melanogasterEditorial CommentGene Down-RegulationGeneralized GrowthGenomic approachGrowthHealthHumanInvestigationIsoformsKnowledgeM PhaseMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMitosisMitosis StageMitoticModel SystemModelingModern ManMolecularNewly DiagnosedOncogenesisOncoprotein p53OrganismOutcomeP53Pathway interactionsPhosphoprotein P53Phosphoprotein pp53PolyploidPolyploid CellsPolyploidyProcessPropertyProtein IsoformsProtein TP53Published CommentRelapseRepressionResistanceSignal PathwayStressSubcellular ProcessTP53TP53 geneTRP53Tissue GrowthTissuesTranscription RepressionTumor Protein p53Tumor Protein p53 GeneVariantVariationViewpointanti-cancer therapybiological adaptation to stresscancer therapycancer-directed therapycarcinogenesiscell culturecell culturescell typedevelopmentalfruit flygene repressiongenome integritygenomic effortgenomic integritygenomic strategyin vivoliving systemmalformationmalignancyneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyp53 Antigenp53 Genesp53 Tumor Suppressorpathwayprogramsprotein p53reaction; crisisregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresistantresponsestress responsestress; reactiontissue regenerationtissue regrowthtissue renewaltissue specific regenerationtumorigenesis
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Project Summary
The Calvi lab investigates the regulation of cell cycle and genome integrity using Drosophila melanogaster as a
model system. Our ongoing studies are defining the variations in cell cycle and checkpoints in development
and how these variations are related to disease. One cell cycle variant that we have focused on is called the…
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