grant
Causes and consequences of genome instability and chromosome rearrangements
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 11 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026Automobile DrivingB-Cell ActivationBiologicalCancersCell BodyCell Cycle ProgressionCell SurvivalCell ViabilityCellsChromosomesComplexCritical PathsCritical PathwaysDNADNA DamageDNA Damage RepairDNA Double Strand BreakDNA InjuryDNA RepairDNA Repair PathwayDNA mutationDefectDeoxyribonucleic AcidDiagnosisDouble Strand Break RepairDrug TargetingEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEventEvolutionFoundationsG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGene TranscriptionGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetic predisposing factorGenomeGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGenomic approachGoalsIGHIGH@ gene clusterIgH locusImmunoglobulin Heavy Chain GenesImmunoglobulin Heavy GeneImmunoglobulin Heavy LocusIntermediary MetabolismInterventionLaboratoriesLaboratory ResearchMalignant NeoplasmsMalignant TumorMeasuresMetabolic ProcessesMetabolismMethodsMolecularMutationNHEJNIGMSNational Institute of General Medical SciencesNon-Homologous End JoiningNon-homologous DNA End JoiningNonhomologous DNA End JoiningNonhomologous End JoiningPathway interactionsPlayPopulationPublishingRNA ExpressionRoleSiteStressStructureTherapeuticTranscriptionUnscheduled DNA SynthesisWorkactivated B cellsbiologiccancer predispositioncell immortalizationcell transformationdefined contributiondisease preventiondisorder preventiondrivinggene locusgenetic locusgenetic risk factorgenome mutationgenome scalegenome-widegenomewidegenomic effortgenomic locationgenomic locusgenomic strategyhomologous recombinationimmune system functionimmunoglobulin heavy chain locusinherited factormalignancyneoplasm/cancernovelpathwayprogramsregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissuerepairrepairedreplication stresssocial roletherapeutic targettissue regenerationtissue regrowthtissue renewaltissue specific regenerationtransformed cells
Description preview
Abstract:
This R35 MIRA application represents the five-year program plan for my laboratory. The
overarching goal of my laboratory research program focuses on how DNA double-strand breaks
(DSBs), a particularly toxic form of DNA damage, induce genome instability and chromosome
rearrangements. DSBs are predominantly repaired by non-homologous end…
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