CAREER: An investigation of the role of Piezo1 polymorphisms in traumatic brain injury pathology using isogenic human in vitro models

The protein Piezo1 in human body allows cells to feel mechanical forces such as stress, strain, and trauma. Cells use Piezo1 to drive the sense of touch and direct joints, muscles, and tendons to gain strength when they are overloaded. E756del is a genetic variant in the gene for Piezo1 and those who have this variant are highly sensitive to…