grant
Cardiac function and proteomic biomarkers in individuals with perinatal HIV infection or exposure
NIHUS FederalResearch GrantFY20250-11 years oldAIDS VirusAIDS preventionAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdolescentAdolescent YouthAdverse effectsAffectAfrica South of the SaharaAtrialAutonomic DysfunctionBioinformaticsBiological MarkersBirthCardiacCardiac AbnormalitiesCardiac AtriumCardiac ToxicityCardiotoxicCardiotoxicityCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCaringChildChild YouthChildren (0-21)ClinicalClinical assessmentsDataDiseaseDisorderDysfunctionEarly InterventionEchocardiogramEchocardiographyEpidemicEpidemiologyFibrosisFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumFunctional disorderGeneralized GrowthGoalsGrowthHIVHIV InfectionsHIV PreventionHIV/AIDS preventionHTLV-III InfectionsHTLV-III-LAV InfectionsHealthHeart AbnormalitiesHeart AtriumHeart VascularHeart failureHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImageImmuneImmune Cell ActivationImmunesIncidenceIndividualInflammationInfrastructureInterventionKenyaKnowledgeLAV-HTLV-IIILife ExpectancyLinkLymphadenopathy-Associated VirusMeasuresMethodologyMissionModelingMolecularMolecular FingerprintingMolecular ProfilingMyocardialMyocardial depressionMyocardial dysfunctionNHLBINational Heart, Lung, and Blood InstituteNational Institutes of HealthOutcomeOutcome MeasureParticipantParturitionPathway interactionsPerformancePerinatalPeripartumPersonsPhenotypePhysical FunctionPhysical PerformancePhysiopathologyPlasma ProteinsPopulationProspective StudiesProteinsProteomicsPublic HealthResearchRiskStandardizationSub-Saharan AfricaSubsaharan AfricaTestingTissue GrowthTransthoracic EchocardiographyUnited States National Institutes of HealthVentricularViral DiseasesVirus DiseasesVirus-HIVWalkingWorkYouthYouth 10-21academic programaccess to health careaccessibility of health careaccessibility to health careadult youthantiretroviral therapyantiretroviral treatmentbio-markersbiologic markerbiomarkerblood-based biomarkerblood-based markercardiac dysfunctioncardiac failurecardiac fibrosiscardiac functioncardiac imagingcardiac scanningcardioprotectantcardioprotectioncardioprotectivecardiovascular disordercardiovascular riskcardiovascular risk factorcirculating biomarkerscirculating markerscirculatory systemclinical careco-morbidco-morbiditycomorbiditycoronary fibrosisepidemiologicepidemiologicalexposed in uterofetal exposurefibrotic heartfunction of the hearthealth care accesshealth care availabilityhealth care service accesshealth care service availabilityheart disease preventionheart disorder preventionheart dysfunctionheart fibrosisheart functionheart imagingheart rate variabilityheart scanningheart sonographyhigh risk grouphigh risk individualhigh risk peoplehigh risk populationimagingimmune activationin utero exposureindexinginnovateinnovationinnovativeinsightintra-uterine environmental exposureintrauterine environmental exposurejuvenilejuvenile humankidsmeasurable outcomemolecular profilemolecular signaturemyocardial fibrosisnovelontogenyoutcome measurementpathophysiologypathwayperinatal HIVphenotypic biomarkerphenotypic markerpopulation basedprenatal exposureprenatally exposedpreventprevent heart diseasepreventingprogramsrate of changesecondary outcomeunsupervised learningunsupervised machine learningviral infectionvirus infectionvirus-induced diseaseyoung adultyoung adult ageyoung adulthoodyoungsteryouth age
Description preview
There are approximately three million individuals with perinatally acquired human immunodeficiency virus
(pnHIV) worldwide and >150,000 new youth with pnHIV (YpnHIV) annually. The incidence of pnHIV has declined
dramatically over the last two decades, yet rates remain high in Eastern and Southern sub-Saharan Africa (SSA)
- threefold greater than…
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