grant
Cancer Metabolism & Microenvironment
Organization SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTELocation LA JOLLA, UNITED STATESPosted 1 May 1997Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAbnormal Assessment of MetabolismAddressApplications GrantsAreaAutophagocytosisBiologyCCSGCancer BiologyCancer CenterCancer Center Support GrantCancersCell SurvivalCell ViabilityCellular biologyChemicalsCollaborationsDNA Molecular BiologyER stressEquilibriumEventFacultyGenomicsGoalsGrant ProposalsHigh Throughput AssayInnovative TherapyKnowledgeLeadershipLibrariesMacropainMacroxyproteinaseMalignant CellMalignant NeoplasmsMalignant TumorMedicinal ChemistryMetabolic Protein DegradationMetabolic StudiesMetabolism StudiesMolecular BiologyMulticatalytic ProteinasePharmaceutic ChemistryPharmaceutical ChemistryProsomeProteasomeProteasome Endopeptidase ComplexProtein BiosynthesisProtein TurnoverProteosomeRegulatory Protein DegradationResearchRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSystemTranslatingTranslational ResearchTranslational Scienceautophagybalancebalance functioncancer cellcancer cell metabolismcancer metabolismcancer microenvironmentcell biologyefficacious therapyefficacious treatmentendoplasmic reticulum stressexpectationhigh throughput screeningmalignancymembermetabolic abnormality assessmentmulticatalytic endopeptidase complexneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpharmacologicpre-clinical studypreclinical studyprogramsprotein degradationprotein synthesisrecruittargeted cancer therapytranslation researchtranslational investigationtumor cell metabolismtumor metabolismtumor microenvironment
Full Description
The overall goal of the Cancer Metabolism & Microenvironment (CMM) Program (formerly Cell and Molecular Biology of Cancer Program) is to generate new knowledge about potential targets for cancer therapy and to translate this information into more selective and efficacious treatments.
Grant Number: 4P30CA030199-44
NIH Institute/Center: NIH
Principal Investigator: Paul Boutros
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