grant
Cancer Health Disparities SPORE in Endometrial Cancer
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 4 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Active Follow-upAddressAggressionAggressive behaviorBioinformatics coreBioinformatics research coreBioinformatics resource coreBiologic FactorBiologicalBiological FactorsBiological MarkersBiometricsBiometryBiostatisticsBiostatistics CoreBlackBlack raceBloodBlood Reticuloendothelial SystemCancer PatientCancersCaringCaucasian FemalesCaucasian WomenClinicalClinical DataClinical TreatmentCollaborationsCollectionCommunity OutreachComplementComplement ProteinsConsentDataData CollectionData SetDedicationsDevelopmentDevelopment and ResearchDietDisparitiesDisparityDrugsEndometrial CancerEndometrial CarcinomaEndometrium CancerEndometrium CarcinomaEnrollmentEpidemiologic DeterminantsEpidemiologic FactorsEpidemiological FactorsEpigenetic ageFecesFrequenciesFutureGI microbiomeGenomeGerm-FreeGoalsHumanImmuneImmune mediated therapyImmunesImmunologically Directed TherapyImmunotherapyIndustryInnate Immune SystemInnate ImmunityInvestigatorsLeadMalignant NeoplasmsMalignant TumorMeasurableMeasuresMedical RecordsMedicationMetabolicMiceMice MammalsMissionModelingModern ManMolecularMurineMusNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNorth CarolinaOrganoidsOutcomePD 1PD-1PD1PathologyPathway interactionsPatientsPb elementPharmaceutical PreparationsPre-Clinical ModelPreclinical ModelsPrevalencePreventative interventionProspective StudiesProtocolProtocols documentationR & DR&DRectumRecurrenceRecurrentResearchResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesRiskSamplingStudy TypeSurvey InstrumentSurveysSurvival RateSwabTherapeutic InterventionTranslational ResearchTranslational ScienceTranslationsTumor BankTumor BiologyWhite FemalesWhite Womenaccelerated epigenetic ageaccelerated epigenetic agingaccelerated pace of epigenetic agingacceleration in epigenetic ageactive followupaging induced epigenetic changeaging-associated epigenetic changeaging-related epigenetic changeallostatic loadanti-cancer researchbio-markersbiologicbiologic markerbiomarkerblack femaleblack womencancer disparitycancer health disparitycancer researchcancer sub-typescancer subtypescancer-related health disparitycareerclinical interventionclinical therapycohortcommunity engagementcomplementationdevelopmentaldietsdigestive tract microbiomedisparities in mortalitydisparity in cancerdisparity in healthdrug/agentdysbacteriosisdysbiosisdysbioticempowermentengagement with communitiesenrollenteric microbiomeepigenetic agingepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingepigenomeepigenomicsfaster epigenetic agingfaster rates of epigenetic agingfemale outcomesfollow upfollow-upfollowed upfollowupgastrointestinal microbiomegut microbiomegut-associated microbiomehealth disparityheavy metal Pbheavy metal leadimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedimproved outcomeincreased epigenetic ageincreased epigenetic agingincreased rates of epigenetic aginginhibitorinnovateinnovationinnovativeintervention for preventionintervention therapyintestinal biomeintestinal microbiomemalignancymicrobialmicrobial imbalancemicrobiomemortalitymortality disparitymouse modelmultidisciplinarymurine modelneoplasm/cancernext generationnoveloutcomes among femalesoutcomes among womenoutcomes in femalesoutcomes in womenpathwaypopulation basedpre-clinicalpreclinicalprevention interventionpreventional intervention strategypreventive interventionprogrammed cell death 1programmed cell death protein 1programmed death 1programsrapid epigenetic agingrecruitresearch and developmentresponse to therapyresponse to treatmentsle2socialsocial factorssocial influencestoolstudy designsystemic lupus erythematosus susceptibility 2targeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapeutic targettherapy responsetranslationtranslation researchtranslational investigationtreatment responsetreatment responsivenesstrial regimentrial treatmenttumorwomen's outcomes
Description preview
Endometrial cancer (EC) is increasing in frequency and mortality and harbors one of the largest health disparities in US cancers. To address this disparity, we propose the Cancer Health Disparities SPORE in Endometrial Cancer that is comprised of a multi-disciplinary translational research team and a comprehensive approach to studying disparities…
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