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Cancer Cell Biology Research Program
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Jun 1997Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025APF-1ATP-Dependent Proteolysis Factor 1ActinsAddressApoptosisApoptosis PathwayAreaBasic ResearchBasic ScienceBiochemistryBiological ChemistryBiologyBiophysicsBlood VesselsBody TissuesBreast CancerCCSGCancer Center Support GrantCancer InterventionCancer TreatmentCancersCatchment AreaCell BodyCell Communication and SignalingCell CycleCell Cycle ControlCell Cycle RegulationCell Division CycleCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular biologyChromatinClinicalClinical SciencesClinical TrialsCollaborationsCommunitiesCommunity OutreachComplexCore FacilityCullin Domain ProteinCullin Family GeneCullin Family ProteinCullin ProteinsCullinsCytoskeletal SystemCytoskeletonDNADNA Damage RepairDNA ModificationDNA Modification ProcessDNA RepairDNA ReplicationDNA SynthesisDNA biosynthesisDeoxyribonucleic AcidDevelopmentDevelopment and ResearchDioxygenasesDirect CostsDisparitiesDisparityDoctor of PhilosophyE3 LigaseE3 Ubiquitin LigaseEXTMREducationEducational aspectsEducational process of instructingElectronic cigaretteEntrepreneurial SkillEntrepreneurshipEnvironmentEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquipmentEventExtramuralExtramural ActivitiesFacultyFaculty RecruitmentFamilyFosteringFundingGenomicsGoalsGrantGrowth AgentsGrowth FactorGrowth SubstancesHMG-20High Mobility Protein 20HistoryInstitutionIntermediary MetabolismInterventionIntracellular Communication and SignalingInvestigatorsInvestmentsJointsKnowledgeLungLung Respiratory SystemMalignant Breast NeoplasmMalignant CellMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMalignant neoplasm of pancreasMelanomaMentorsMentorshipMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorModelingMolecularMolecular Tumor SuppressionMotilityMultiple MyelomaNeoplasm MetastasisNon-Polyadenylated RNANorth CarolinaOncogenesisOutputPancreasPancreas CancerPancreaticPancreatic CancerPathway interactionsPh.D.PhDPhasePhenotypePilot ProjectsPlasma-Cell MyelomaPopulationPopulation SciencesProductivityProgram DevelopmentProgrammed Cell DeathProstateProstate GlandProstatic GlandProteins Growth FactorsPublishingPulmonary CancerPulmonary malignant NeoplasmR & DR&DRNARNA Gene ProductsReceptor ProteinRecording of previous eventsRegulationResearchResearch ActivityResearch PersonnelResearchersResistanceResource SharingRibonucleic AcidRoleScientistSecondary NeoplasmSecondary TumorSeminalSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureSubcellular ProcessTalentsTeachingTechnologyTestingTherapeuticTherapeutic InterventionTissuesTrainingTranscriptional ControlTranscriptional RegulationTranslatingTranslationsTumor CellTumor Cell InvasionTumor InvasionTumor SuppressionUbiquitinUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3Unscheduled DNA Synthesisangiogenesisanti-cancer researchanti-cancer therapybiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescancer cellcancer metastasiscancer progressioncancer researchcancer therapycancer-directed therapycareercell biologycell motilitycommercializationcommunity engagementconferenceconventiondevelopmentaldrug discoverye-cige-cigaretteecigecigaretteeffective therapyeffective treatmentengagement with communitiesepigeneticallyhigh schoolhistone modificationhistoriesimprovedinsightinterestintervention therapyintracellular skeletonjunior highjunior high schoollung cancermalignancymalignant breast tumormeetingmeetingsmembermiddle schoolmigrationmyelomamyelomatosisneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew diagnosticsnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation diagnosticsnext generation therapeuticsnovel diagnosticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpancreatic malignancypathwaypeerpilot studypre-clinicalpre-clinical trialpreclinicalpreclinical trialprofessorprogramsreceptorrecruit teachersresearch and developmentresistantresponsesmall molecular inhibitorsmall molecule inhibitorsocial rolesummitsymposiasymposiumtargeted cancer therapyteacher recruitmenttherapeutic targettranslationtumortumor cell metastasistumor initiationtumor progressiontumorigenesisubiquitin-protein ligasevascular
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Description preview
ABSTRACT: CANCER CELL BIOLOGY PROGRAM
The overarching goals of the Cancer Cell Biology (CCB) Program are: (i) to understand, at the molecular and
cellular levels, mechanisms underlying tumor initiation, progression, metastasis and resistance to therapeutic
treatment, and (ii) to identify and validate new targets for cancer therapy. Insight derived…
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