Cancer Biology Program

Project Summary/Abstract: Cancer Biology Program (CBP)
The overall goal of research in the Cancer Biology Program (CBP), previously the Molecular and Biochemical
Etiology Program, is to understand mechanisms that underlie cancer initiation and progression that could lead
to new biomarkers and interventional strategies to positively impact cancer diagnosis, prevention, and
therapeutic strategies across cancers prevalent in the BCC catchment area. To clearly delineate our mission
and themes, we strategically reorganized the program to focus on basic cancer mechanisms, with translational
efforts pursued in collaboration with the Targets, Modulators, and Delivery (TMDP) and GI Cancer (GICP)
programs. To this end, we retained 14 prior members and added 24 new investigators with a basic cancer biology
focus. The major goals of the CBP are to define the molecular mechanisms that maintain genome stability and
their alterations in cancer, dissect intracellular signaling mechanisms and tumor cell-microenvironment
interactions, and elucidate and harness metabolic and other mechanisms that lead to host systemic organ
dysfunction and contribute to cancer patient morbidity and mortality. The 38 CBP members come from eight
departments across the University with multidisciplinary interests in DNA damage/repair processes, signaling
mechanisms, metabolomics, redox biology, and cell- and animal-based cancer models. The research interests
of program members are organized around three Themes. Theme 1. Genome Instability and Cancer. Members
focus on studies of genome replication, DNA damage responses and repair, and identification of new genomic
alterations that drive hereditary or sporadic cancer. Theme 2. Signaling Mechanisms in Cancer. Members focus
on elucidating intra- and inter-cellular signaling mechanisms that drive tumorigenesis and metastasis. Theme 3.
Metabolic Alterations and Systemic Dysfunction in Cancer. Members focus on cancer cell metabolism and redox
biology, and the impact of tumor burden on organ systems, with a particular focus on cancer cachexia and
fatigue. There is extensive cross-talk between Themes, and basic mechanisms and pathways elucidated under
CBP provide a rich basis for inter-programmatic collaborations with TMDP and GICP towards further translation
into potential target validation and inhibitor design and translational studies. The Co-Leaders leverage their
complementary expertise to enhance inter- and intra-programmatic collaborations through the development and
employment of new and existing shared resources, evaluation and funding of pilot projects supporting the CBP
mission, involvement in faculty recruitment, and organization of regular programmatic meetings. These activities
have led to a strong collaborative group as demonstrated by impactful inter- and intra-programmatic, cancer-
focused publications and grants, and an increased focus on basic biology with the potential for clinical translation.
Cancer-relevant peer-reviewed CBP funding is $6.87M (direct), of which $1.9M is from the NCI. During the
previous funding period, CBP members reported 304 cancer-relevant publications, with 43% intra-programmatic,
45% inter-programmatic, 28% both intra- and inter-programmatic, and 38% inter-institutional publications.

Grant Number: 5P30CA036727-39
NIH Institute/Center: NIH
Principal Investigator: Hamid Band