grant
Calmodulin and Regulation of Cardiac Ryanodine Receptor and CaMKII
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Jan 2010Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAffinityAmericanAnimal ModelAnimal Models and Related StudiesArrhythmiaAssayBindingBioassayBiological AssayBiophysicsCa Release Channel-Ryanodine ReceptorCalciumCalcium-Dependent Activator ProteinCalcium-Dependent RegulatorCalcium-Ryanodine Receptor ComplexCalmodulinCardiacCardiac ArrhythmiaCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiocyteCatsCats MammalsCell Communication and SignalingCell SignalingChronicCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyCytoplasmDantroleneDataDefectDiabetes MellitusDiastoleDiseaseDisorderDomestic CatsDysfunctionElectron CryomicroscopyEnvironmentEnzyme GeneEnzymesFK-506-Binding ProteinFK506 Binding ProteinsFKBPFKBP RotamaseFRETFeedbackFeline SpeciesFelis catusFelis domesticaFelis domesticusFelis sylvestris catusFluorescenceFluorescence Resonance Energy TransferFunctional disorderFörster Resonance Energy TransferGoalsHealthHeartHeart ArrhythmiasHeart DiseasesHeart Muscle CellsHeart failureHeart myocyteHigh Throughput AssayHumanImageIntracellular Communication and SignalingKinasesKineticsMapsMeasuresMemoryMetabolic GlycosylationModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMovementMuscle CellsMyocytesNodalPathologicPathologyPathway interactionsPhosphodiesterase Activating FactorPhosphodiesterase Protein ActivatorPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPhysiopathologyPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPropertyProtein ModificationProtein PhosphorylationReceptor InhibitionRegulationReporterResearchRyanodine ReceptorRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSignal TransductionSignal Transduction SystemsSignalingStressStructureSystoleTacrolimus Binding ProteinsTestingTherapeuticTimeTransphosphorylasesVentricularWorkadulthoodanimationbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbody movementcardiac failurecardiomyocytecatsconfocal imagingconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydiabetesdrug candidatedrug discoverydrug-like chemicaldrug-like compounddrug-like moleculeglycosylationheart disorderhigh definitionhigh throughput screeninghigh-resolutionimaginginsightmodel of animalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachoxidationpathophysiologypathwayscreeningscreening programscreeningssensorstopped-flow fluorescencesynergismtherapeutic targettoolvalidation studies
Description preview
SUMMARY
Our overall goal is to understand the structural mechanisms for functional regulation of the cardiac
ryanodine receptor (RyR2) and Ca/calmodulin-dependent kinase (CaMKII), two central signaling nodes
causally implicated in numerous cardiac pathologies, including heart failure (HF) and arrhythmias. Our focus is
on pathological states and…
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