grant
Calcium signaling mechanism in proximal tubule underlying calcium nephrolithiasis
Organization U.S. DEPT/VETS AFFAIRS MEDICAL CENTERLocation WASHINGTON, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2029
VANIHUS FederalResearch GrantFY20253-D3-Dimensional3DAcetazolamideAcidosisAffectAlkalinizationAmericanAnimal ModelAnimal Models and Related StudiesApatitesApicalApoptosisApoptosis PathwayAreaB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BetaineBicarbonatesBlood VesselsBlood capillariesBreast MicrocalcificationBrush BorderCalcifiedCalcinosisCalciumCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium GluconateCalcium Ion ChannelsCalcium Ion SignalingCalcium OxalateCalcium SignalingCausalityCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCellular injuryCitratesCrystal DepositionCrystal FormationCrystallizationDataDietDiseaseDisorderDistalDysfunctionElectrophysiologyElectrophysiology (science)Endothelial CellsEnvironmental PollutantsEtiologyExhibitsExtremitiesFemaleFibrosisFunctional disorderGene ExpressionGeneticH2O2HCO3HPGFHenle's loopHepatocyte-Stimulating FactorHospital AdmissionHospitalizationHybridoma Growth FactorHydrogen CarbonatesHydrogen OxideHydrogen PeroxideHydroperoxideIFN-beta 2IFNB2IL-6IL6 ProteinImageImmuneImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIn VitroIncidenceInflammationInjuryInterleukin-6InterruptionInterventionInvoluntary MuscleIonsKO miceKidneyKidney CalculiKidney StonesKidney Urinary SystemKnock-out MiceKnockout MiceLeannessLimb structureLimbsLinkLiquid substanceLycineMGI-2MeasurementMediatingMiceMice MammalsMicrocalcificationMicrofluidicsMixed StoneMolecularMolecular TargetMorbidityMorbidity - disease rateMurineMusMyeloid Differentiation-Inducing ProteinNephrolithiasisNephronsNeurophysiology / ElectrophysiologyNon-TrunkNull MouseOutcomeOxalatesOxidative StressOxyneurinePapillaryPathogenesisPathologic CalcificationPathway interactionsPatientsPersonsPhenotypePhosphatesPhysiopathologyPlasmacytoma Growth FactorPredispositionPrevalenceProcessProgrammed Cell DeathProteinsProximal Kidney TubulesReceptor ProteinRecurrenceRecurrentRegulationRegulatory ProteinRenal CalculiRenal StoneRenal lithiasisResearchRoleSamplingSignal PathwaySiteSmooth MuscleSolubilitySortingStressStriated BorderSubcellular ProcessSusceptibilityTestingThinnessTubularTubular formationUrineUriniferous TubeVDCCVascular calcificationVeteransVoltage-Dependent Calcium ChannelsWaterWomanabsorptioncalcificationcalcium excretioncalcium phosphatecalcium salt Ethanedioic acidcapillarycausationcell damagecell injurycellular damagedamage to cellsdevelop therapydietsdisease causationelectrophysiologicalendoplasmenvironmental contaminantexcrete calciumfluidgenetic regulatory proteinhealth recordhypercalcinuriahypercalciuriahypercalciuricimagingin vivoinjuriesinjury to cellsinorganic phosphateinterferon beta 2interstitialintervention developmentliquidmalemenmodel of animalmouse modelmurine modelnovelpatch clamppathophysiologypathwaypreventpreventingreceptorregulatory gene productremediationrenalrenal calciumrenal proximal tubuleresponsesexsocial roletherapeutic agent developmenttherapeutic developmenttherapy developmentthree dimensionaltranslational studytreatment developmenttrendurinaryvascularµfluidic♀♂
Description preview
Project summary: The prevalence of nephrolithiasis affects more than 10% of Americans in their lifetime.
Veterans’ health records show that nephrolithiasis is one of the leading causes of hospitalizations and is
associated with increased morbidity. Calcium nephrolithiasis (CaNL), which has increased in the past few
decades, comprises ~80% of…
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