grant

C. albicans-intrinsic mechanisms defining gut colonization

Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 1 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAdhesionsAlimentary CanalAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAssayAsthmaAttentionBacteriaBar CodesBasal Transcription FactorBasal transcription factor genesBehaviorBioassayBiological AssayBody TissuesBronchial AsthmaC albicansC. albicansC.albicansCandida albicansCell BodyCell secretionCellsCellular SecretionCellular injuryCustomDataDeath RateDigestive TractDiseaseDisorderEnabling FactorsEngineeringEnvironmentEpithelial CellsExclusionExhibitsFilamentFungus DiseasesGI TractGI colonizationGI commensalGastrointestinal TractGastrointestinal tract structureGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGrowthHealthHumanHyphaeImmune responseImmunologic StimulationImmunological StimulationImmunostimulationInfectionInflammatory Bowel DiseasesInflammatory Bowel DisorderIntestinalIntestinesIntrinsic factorInvadedLifeLinkLung InflammationMiceMice MammalsMiscellaneous AntibioticModelingModern ManMorphologyMucosaMucosal TissueMucous MembraneMurineMusMycosesPathologicPeptidesPlayPneumonitisPopulationProductionPropertyProteinsPublic HealthPulmonary InflammationResearchRoleSeriesSpatial DistributionSupplementationSymbiosisSystemic diseaseSystemic infectionTechniquesTherapeutic FungicidesTissue GrowthTissuesToxinTranscription Factor Proto-OncogeneTranscription factor genesVirulenceYeastsalimentary tractanti-fungalanti-fungal agentsanti-fungal drugbacterial disease treatmentbacterial infectious disease treatmentbacterial microbiomebacteriomebarcodeblood infectionbloodstream infectionbowelcell damagecell injurycell typecellular damagecommensal bacteria in the gastrointestinal tractcommensal bacteria in the gutcommensal bacteria in the intestinecommensalismcustomsdamage to cellsdigestive canalenteric commensalexperimentexperimental researchexperimental studyexperimentsfitnessfungal infectionfungal pathogenfungi pathogenfungusfungus infectiongastrointestinalgastrointestinal commensalgastrointestinal tract colonizationgut colonizationgut commensalhost colonizationhost responseimmune system responseimmunoresponseinfection in the bloodinfection of the bloodinflammatory disease of the intestineinflammatory disorder of the intestineinjury to cellsinsightinterestintestinal autoinflammationintestinal colonizationintestinal commensalmicrobial consortiamicrobial floramicrobiotamicrofloramortality ratemortality ratiomouse modelmultispecies consortiamurine modelnovelontogenypathobiontpathogenic fungusprogramssocial roletranscription factor
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Description preview

Project Summary:
The fungus Candida albicans is a frequent commensal of the gastrointestinal (GI) tract but is also an

important cause of both mucosal and systemic disease. The GI population is particularly relevant to human

health as cells can translocate out of this niche to cause disseminated infections. C. albicans cells in the gut

also play…

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C. albicans-intrinsic mechanisms defining gut colonization — BROWN UNIVERSITY | UNITED STATES | Jul 2024 | Dev Procure