grant
Building predictive algorithms to identify resilience and resistance to Alzheimer's disease
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Jun 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AD dementiaAD pathologyAD preventionAD riskAD risk factorAddressAfrican AmericanAfro AmericanAfroamericanAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAmyloidAmyloid SubstanceApolipoproteinsAreaBiometricsBiometryBiostatisticsBlackBlack raceBlood VesselsBrainBrain Nervous SystemCalibrationCell Communication and SignalingCell SignalingClassificationClinicalClinical TrialsClinical Trials DesignCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive ManifestationsCognitive SymptomsCognitive declineCognitive function abnormalDataDecision MakingDiagnosticDisturbance in cognitionEducationEducational aspectsEncephalonEpidemiologyExhibitsFemaleGeneticGoalsImpaired cognitionIndividualIntracellular Communication and SignalingKnowledgeLifeLong-term cohortLongitudinal cohortMT-bound tauMachine LearningMapsMeasuresMedicalModelingNeuropsychologiesNeuropsychologyNon-HispanicNonhispanicNot Hispanic or LatinoPETPET ScanPET imagingPETSCANPETTPathologicPathologyPatientsPhenotypePopulationPositionPositioning AttributePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrevention trialPrimary Senile Degenerative DementiaProteinsProtocolProtocols documentationPublishingRaceRacesRad.-PETResistanceResistance profileResistant profileRiskRisk EstimateRisk FactorsSample SizeSignal TransductionSignal Transduction SystemsSignalingStructureSymptomsSystematicsTheoretic ModelsTheoretical modelTherapeutic InterventionWhite Matter HyperintensityWomanalzheimer riskbehavioral neurologybiological signal transductionburden of diseaseburden of illnessclinical decision-makingclinical practiceclinical trial recruitmentcognitive changecognitive dysfunctioncognitive losscognitive neurosciencecognitive performancecohortcomputer based predictiondata harmonizationdementia riskdemographicsdisease burdenepidemiologicepidemiologicalflexibilityflexiblegray matterharmonized dataimprovedinnovateinnovationinnovativeintersectionalitiesintersectionalityintervention therapymachine based learningmalemenmicrotubule bound taumicrotubule-bound tauneural imagingneuro-imagingneuroimagingneurological imagingneuropsychologicold ageolder adultolder adulthoodpatient profilepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprediction algorithmpredictive modelingpreservationprimary degenerative dementiaprofiles in patientsracialracial backgroundracial originresilienceresilientresistantresponserisk factor for dementiarisk factor for developing Alzheimer'srisk factor in Alzheimer'srisk for dementiarisk of developing Alzheimer'sscreeningscreeningssenile dementia of the Alzheimer typesexsocial culturesocio-culturalsocioculturalsubstantia griseatautau Proteinstau factortheoriesvascularvascular componentvascular factoryounger ageτ Proteins♀♂
Description preview
PROJECT SUMMARY
There are two observed phenomena that defy the traditional Alzheimer’s disease (AD) trajectory; those who resist the accumulation of AD pathology (amyloid and/or tau) despite evidence of risk factors, and those who present with AD pathology but remain resilient to cognitive decline. Classifying these individuals who will likely…
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