grant
Building a spatial transcriptomics infrastructure for isoform profiling in aging pre-neoplastic tissues
Organization JACKSON LABORATORYLocation BAR HARBOR, UNITED STATESPosted 1 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AddressAdvanced DevelopmentAgeAge related pathologiesAgingAlternate SplicingAlternative RNA SplicingAlternative SplicingAtlasesBiology of AgingBody TissuesBreastBreast CancerBreast Cancer Early DetectionBreast Cancer Early ScreeningBreast Cancer Risk FactorBreast Epithelial CellsBreast NeoplasmsBreast TissueBreast TumorsCancer BiologyCancersCarcinomaCell BodyCell CommunicationCell FunctionCell InteractionCell PhysiologyCell ProcessCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCodeCoding SystemCommunitiesComputational toolkitComputing MethodologiesDataData AnalysesData AnalysisData SetDetectionDevelopmentDissociationDrug resistanceEpithelial cancerEpitheliumEventEvolutionFibroblastsGeneralized GrowthGenesGenomicsGoalsGrowthHumanImmuneImmunesIn VitroIndividualInfrastructureInterventionInvestigatorsIsoformsKnowledgeLengthLigandsLinkMalignant Breast NeoplasmMalignant CellMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant NeoplasmsMalignant TumorMammary CancerMammary Gland ParenchymaMammary Gland TissueMammary NeoplasmsMapsMeasuresMediatingMiceMice MammalsModern ManMolecularMorphologyMurineMusNon-Polyadenylated RNAOncogenesisPatternPhasePhenotypePopulationPreventionProtein IsoformsProteinsRNARNA Gene ProductsRNA SeqRNA SplicingRNA sequencingRNAseqReceptor ProteinResearchResearch PersonnelResearch ResourcesResearchersResourcesRibonucleic AcidRisk FactorsRoleSamplingScreening for cancerSpatial DistributionSplicingStandardizationSubcellular ProcessSystems BiologyTechnologyTissue GrowthTissuesTranscriptTumor SubtypeUpregulationVisualizationVisualization softwareWomanWorkage associatedage associated alterationsage associated changesage associated pathologiesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent pathologiesage induced alterationsage induced changesage induced pathologiesage linkedage relatedage related alterationsage related changesage specificage specific alterationsage specific changesaged miceaged mouseagesaging associated alterationsaging associated changesaging associated pathologiesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging dependent pathologiesaging induced alterationsaging induced changesaging induced pathologiesaging pathologiesaging related alterationsaging related changesaging related pathologiesaging specific alterationsaging specific changesalterations with agebreast cancer riskcancer cellcancer initiationcancer sub-typescancer subtypescell typechanges with agecomputational methodologycomputational methodscomputational toolboxcomputational toolscomputational toolsetcomputer based methodcomputer methodscomputerized toolscomputing methoddata infrastructuredata interpretationdata miningdata resourcedata sharingdata visualizationdataminingdevelopmentaldrug resistantearly biomarkersearly cancer detectionearly detection biomarkersearly detection markerselderly miceepithelial carcinomaglobal gene expressionglobal transcription profilein vivoinnovateinnovationinnovativeinsightinternet resourcelong read seqlong-read sequencinglong-read transcript sequencingmalignancymalignant breast tumormammarymammary epithelial cellsmammary gland epithelial cellsmammary tumorneoplasm/cancerneoplasticnew approachesnew markernovel approachesnovel biomarkernovel markernovel strategiesnovel strategyold ageold miceolder womenon-line compendiumon-line resourceonline compendiumonline resourceontogenyreceptorresistance to Drugresistant to Drugresponseresponse to therapyresponse to treatmentscreening cancer patientssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssuccesstherapeutic responsetherapy responsetooltranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment responsetreatment responsivenesstumortumor initiationtumorigenesisvisualization toolweb resourceweb-based resourceyoung woman
Description preview
PROJECT SUMMARY/ABSTRACT
Aging is the greatest risk factor for cancer, but it is not known which age-dependent cellular and molecular events
drive cancer initiation. Spatial transcriptomic approaches are revolutionizing our understanding of cancer
initiation, progression, and drug resistance by revealing expression patterns with tissue…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click