grant
Bridging the gap between basic and clinical research to prevent cardiovascular disease in diabetes
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 May 2026Deadline 28 Feb 2033
NIHUS FederalResearch GrantFY20260-11 years old10 year old10 years of age21+ years oldASCVDAccelerationAddressAdipose tissueAdultAdult HumanAdult-Onset Diabetes MellitusAffectApolipoproteinsAtherogenicityAtherosclerosisAtherosclerotic Cardiovascular DiseaseBasic ResearchBasic ScienceBlood PlasmaBlood VesselsBrittle Diabetes MellitusCardiovascular DiseasesCell BodyCellsChildChild YouthChildren (0-21)Clinical ResearchClinical StudyDiabetes MellitusDiabetic mouseDysfunctionEventFatty TissueFunctional disorderGoalsHealthHepaticIDDMIncidenceIndividualInsulin ResistanceInsulin-Dependent Diabetes MellitusInvestigationJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusLDL CholesterolLDL Cholesterol LipoproteinsLinkLipoproteinsLow Density Lipoprotein CholesterolMaturity-Onset Diabetes MellitusModelingNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusPathway interactionsPersonsPhysiopathologyPlasmaPlasma SerumPopulationPositionPositioning AttributePre-DMPrediabetesPrediabetes syndromePrediabetic StatePredicting RiskPreventative strategyPrevention strategyPreventive strategyProductionRecommendationResearchResidualResidual stateReticuloendothelial System, Serum, PlasmaRisk ReductionSlow-Onset Diabetes MellitusStable Diabetes MellitusSudden-Onset Diabetes MellitusSystemT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTimeTriacylglycerolTriglyceride MetabolismTriglyceridesType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesYouthYouth 10-21adiposeadult onset diabetesadulthoodage 10age 10 yearsarterial stiffeningarterial stiffnessartery stiffeningartery stiffnessatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebeta-Lipoprotein Cholesterolcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorclinical significanceclinically significantdiabetesdiabetes mouse modelforecasting riskhigh riskinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin tolerancejuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabeteskidsmaturity onset diabetesnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachparticlepathophysiologypathwaypre-diabetespre-diabeticprediabeticpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpreventpreventingprogramsreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk predictionrisk predictionsrisk-reducingsortilinten year oldten years of agetype 2 DMtype I diabetestype II DMtype one diabetestype two diabetesvascularvascular inflammationwhite adipose tissueyellow adipose tissueyounger ageyoungsteryouth age
Description preview
Abstract
Currently, over 11% of the US population (nearly 40 million people) are affected by type 1 or type 2 diabetes
(T1D or T2D), with T2D representing >90% of diabetes cases. In addition, 97.6 million youth and adults have
pre-diabetes and are therefore at high risk of developing T2D and associated vascular complications.
Alarmingly, T2D is…
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