grant
Brainstem control of apneic reflexes relating to respiratory deaths in neurological disorders
Organization SEATTLE CHILDREN'S HOSPITALLocation SEATTLE, UNITED STATESPosted 4 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20250-11 years oldAffectAnesthesiaAnesthesia proceduresAnimalsApneaAspiration PneumoniaBehaviorBilateralBiologic ModelsBiological ModelsBiomedical EngineeringBradycardiaBrainBrain Nervous SystemBrain StemBrainstemCardiacCardiopulmonary ResuscitationCarotid BodyCause of DeathCessation of lifeChildChild YouthChildren (0-21)ChokingClinicalComplexCot DeathCoupledCouplingCrib DeathDREADDsDataData AnalysesData AnalysisDeathDeglutition DisordersDenervationDiaphragmDiseaseDisorderDrowningDysphagiaECGEKGElectrocardiogramElectrocardiographyEncephalonEngineeringEpilepsyEpileptic SeizuresEpilepticsEsthesiaFailureGeneticGenetic IdentityGlomus CaroticumGlycopyrrolateHind BrainHistologyHypoxiaHypoxicImpairmentIn Situ HybridizationInfantInfant MortalityInfant Mortality TotalInjectionsLabelLinkLiteratureMapsMeasuresMedical DeviceMethodsMiceMice MammalsModel SystemModelingModernizationMurineMusNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurosciencesNucleus Tractus SolitariiNucleus solitariusObstructive Sleep ApneaOpsinOpticsOutcomeOutputOxygen DeficiencyPatientsPeripheralPhysiologicPhysiologicalPonsPons CerebelliPons VaroliiPontinePontine structurePopulationPositionPositioning AttributePredictive ValueReflexReflex actionResearch InstituteResearch Project SummariesResearch ResourcesResourcesRespirationRespiratory DiaphragmRhombencephalonRobinulRod-OpsinRoleSIDSSUDEPSeizure DisorderSeizuresSensationSolitary NucleusStimulusSudden DeathSudden Infant DeathSudden Unexpected Infant DeathSudden infant death syndromeSwallowing DisordersSynapsesSynapticSyndrome, Sleep Apnea, ObstructiveTechniquesTimeTracerTrainingTransgenic MiceTransgenic OrganismsTranslationsViral VectorWorkanatomical traceranatomical tract tracerbio-engineeredbio-engineersbioengineeringbiological engineeringbrain researchcardiac resuscitationcholinergicdata interpretationdeath among infantsdeath in first year of lifedeath in infancydeath in infantsdensitydesigner receptors exclusively activated by designer drugsdynamic systemdynamical systemepilepsiaepileptogenicheart resuscitationhindbrainin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivoinfant deathinfant demiseinfantile deathinterestintervention effectkidsmortality in infantsneuralneural controlneural regulationneurological diseaseneuromodulationneuromodulatoryneuronalneuroregulationopticaloptogeneticspeerrespiratoryrespiratory mechanismskillssocial rolesolitary tract nucleussudden unexpected death in epilepsysynapsetooltransgenictranslationyoungster
Description preview
PROJECT SUMMARY
Research: This proposal aims to investigate the fatal failures to gasp and autoresuscitate following an
obstructive reflexive apnea (i.e., choking stimulus) in the pons and medulla. These failures are believed to
underly sudden respiratory deaths in epilepsy (SUDEP), infants (SIDS), and children (SUDC). More broadly,
the neural…
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