grant
Brain Vascular Signatures in Drug-induced Recurrent Hypoglycemia and Associated Cognitive Dysfunction
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AD dementiaAcuteAdult-Onset Diabetes MellitusAdverse ExperienceAdverse eventAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAmmon HornAnesthesiaAnesthesia proceduresAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAnhydroglucochloralAnimalsArtifactsBehaviorBehavior assessmentBehavioralBloodBlood GlucoseBlood Reticuloendothelial SystemBlood SugarBlood Vessel ImagingBlood VesselsBlood VolumeBlood flowBody WeightBrainBrain Nervous SystemBrain VascularBrain imagingCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCerebrovascular CirculationCerebrovascular systemCerebrumChloraloseCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommon Rat StrainsComplexCornu AmmonisDataDementiaDevelopmentDevicesDiabetes MellitusDiagnosisDiagnosticDifferences between sexesDiffers between sexesDisturbance in cognitionDrugsEEGElectroencephalogramElectroencephalographyEncephalonEngineeringFemaleFrequenciesFunctional ImagingFunctional MRIFunctional Magnetic Resonance ImagingGlucochloralGlucochloraloseGrantHeadHippocampusHumulin RHypoglycemiaImageImaging ProceduresImaging TechnicsImaging TechniquesImpaired cognitionImpairmentImplantIndividualInjectionsInsulinInterventionInvestigatorsKetosis-Resistant Diabetes MellitusLengthLinkLocationMapsMaturity-Onset Diabetes MellitusMediatingMedicationMethodsModalityMonitorMorphologic artifactsMotionNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RO elementO2 elementOxygenOxygen ConsumptionPancreatic beta CellPancreatic β-CellPatientsPatternPharmaceutical PreparationsPhysiologic ImagingPredispositionPrefrontal CortexPreventionPrimary Senile Degenerative DementiaR-Series Research ProjectsR01 MechanismR01 ProgramRatRat model of diabetesRats MammalsRattusRecurrenceRecurrentRegular InsulinReportingResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersResolutionRiskRoleSTZSeriesSex DifferencesSexual differencesSlow-Onset Diabetes MellitusStable Diabetes MellitusStreptozocinStreptozotocinStressStructure of beta Cell of isletSubcellular ProcessSusceptibilityT2 DMT2DT2DMTelemetriesTelemetryTestingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUltrasonic TransducerUltrasound transducerVisualizationWeightZanosaradult onset diabetesadvanced age ratsage associatedage associated differenceage based differenceage correlatedage dependentage dependent differenceage dependent variationage differenceage groupage linkedage relatedage related differenceage related variationage specificage specific differenceaged rataged ratsbehavioral assessmentblood flow in brainblood vessels in the brainbrain abnormalitiesbrain blood circulationbrain blood flowbrain blood vesselsbrain tissuebrain vasculaturebrain visualizationcerebralcerebral blood flowcerebral blood vesselcerebral blood volumecerebral circulationcerebral vascularcerebral vasculaturecerebro-vascularcerebrocirculationcerebrovascularcerebrovascular blood flowcerebrovascular imagingcerebrovascular vesselscerebrovasculaturecognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingdesigndesigningdevelopmentaldiabetesdiabetic patientdiabetic ratdiabetic rat modeldiffer by agedifference across agedifference in agedrug/agentelderly ratsexperimentexperimental researchexperimental studyexperimentsfMRIgeriatric ratsglobal healthglucometerglucose meterglucose monitorglucose sensorhippocampalhypoglycemia unawarenesshypoglycemichypoglycemic episodesimage-based methodimagingimaging methodimaging modalityimplantable sensorimplanted sensorinnovateinnovationinnovativeinsightketosis resistant diabeteslife spanlifespanlight weightlightweightmalematurity onset diabetesmetabolic ratemid lifemid-lifemiddle agemiddle agedmidlifenovelobject recognitionold ratsoptical fiberpancreas beta cellpancreas β cellpancreatic b-cellphysiological imagingprimary degenerative dementiaprogramsresolutionsresponsesenile dementia of the Alzheimer typesexsex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolestress reductiontelemetrictype 2 DMtype II DMtype two diabetesultrasoundvariation by agevascularvascular imagingvasculature Imagingweightswirelessyounger age♀♂
Description preview
ABSTRACT
Type 2 diabetes mellitus (T2DM) poses a serious global health issue, affecting millions globally, with a
concerning rise in younger age groups. T2DM patients often suffer from hypoglycemia, typically medication-
induced, leading to severe consequences and cognitive impairment. Frequent hypoglycemic episodes can give
rise to 'hypoglycemia…
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