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Brain Oxygen Optimization in Severe Traumatic Brain Injury - Phase 3 (BOOST-3)

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Jul 2018Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025AbbreviationsAcquired brain injuryAdmissionAdmission activityAdoptedAdverse ExperienceAdverse eventAmericanAreaBehavior assessmentBrainBrain HypoxiaBrain InjuriesBrain Nervous SystemBrain TraumaCaringCause of DeathClassificationClinical ResearchClinical StudyClinical TrialsClinical Trials NetworkCognitiveComaComatoseConsciousConsciousnessControl GroupsDataDeath RateDevicesED careER careElevated Intracranial PressureEmergency CareEmergency Department careEmergency Room careEmergency health careEmergency medical careEncephalonEnrollmentFamilyFood and Drug AdministrationGlasgow Coma ScaleGlasgow Outcome ScaleHeadHospital AdmissionHospitalizationHospitalsHourHypoxiaHypoxicInformed ConsentInjuryIntensive Care UnitsInterventionIntracranial HypertensionIntracranial PressureIntracranial Pressure ElevationIntracranial Pressure IncreaseLeftLifelong disabilityMeasuresMedicalMonitorMorbidityMorbidity - disease rateNeurologicNeurologic outcomeNeurologicalNeurological outcomeO elementO2 elementOutcomeOutcome MeasureOxygenOxygen DeficiencyPartial PressureParticipantPatient MonitoringPatientsPermanent disabilityPhasePost-Head Injury ComaPost-Trauma ComaPost-Traumatic ComaPosttraumatic ComaProceduresProtocolProtocols documentationRandomizedRandomized, Controlled TrialsRecoverySafetySeveritiesSocietiesSpecific qualifier valueSpecifiedSubarachnoid PressureSupportive TherapySupportive careSystematicsTechnologyTimeTraumatic Brain InjuryTraumatic ComaTreatment ProtocolsTreatment RegimenTreatment ScheduleUSFDAUnited StatesUnited States Food and Drug Administrationbehavior outcomebehavioral assessmentbehavioral outcomebrain damagebrain tissuebrain-injuredclinical centerclinical efficacyclinical relevanceclinical research siteclinical siteclinically relevantcognitive assessmentcognitive testingcost estimatecost estimationcritical injurydesigndesigningdevastating injurydisabilityeffective interventionenrollexperiencefunctional improvementimprove functionimprovedimproved functional outcomesinjuriesinnovateinnovationinnovativemeasurable outcomemortality ratemortality rationerve injuryneural injuryneurosurgeryoutcome measurementparticipant enrollmentpatient enrollmentphase 3 trialphase III trialpreventpreventingprimary outcomepsychosocialraised ICPraised intracranial pressurerandomisationrandomizationrandomized control trialrandomized, clinical trialsrandomly assignedsecondary outcomesevere injurytraumatic brain damagetrend

Applications closed.

Description preview

Traumatic brain injury (TBI) is a major cause of death and disability. Of the 3.5 million Americans who sustain a
TBI every year, approximately 27,000 experience prolonged traumatic coma, the most severe form of TBI.
Less than 20% of these patients make a good recovery, and most are left with life-long disabilities. ICU
management of severe TBI…

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Brain Oxygen Optimization in Severe Traumatic Brain Injury - Phase 3 (BOOST-3) — UNIVERSITY OF MICHIGAN AT ANN ARBOR | U | Dev Procure