grant
Brain mitochondrial PET imaging and 31P-MR spectroscopy to dissect the role of mitochondrial dysfunction in bioenergetic dysregulation in Dementia with Lewy Bodies pathogenesis
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 15 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAddressAdenosine TriphosphateAdenylpyrophosphateAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmentiaAnimal ModelAnimal Models and Related StudiesAutopsyBehavioralBioenergeticsBiologicalBlood PlateletsBrainBrain Nervous SystemBrain imagingBrain regionCell Communication and SignalingCell SignalingCell modelCellular modelClinicalCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexCreatine PhosphateDataDefectDementiaDementia with Lewy BodiesDevelopmentDiseaseDisorderDisturbance in cognitionDysfunctionEncephalonEnergy ExpenditureEnergy MetabolismEvaluationEventFDG PETFailureFunctional disorderGlycolysisHumanImageImaging ProceduresImaging TechnicsImaging TechniquesImpaired cognitionIntermediary MetabolismIntracellular Communication and SignalingLinkMR SpectroscopyMagnetic Resonance SpectroscopyMarrow plateletMeasurementMeasuresMetabolic PathwayMetabolic ProcessesMetabolic dysfunctionMetabolismMethodologyMitochondriaModern ManMotorNAC precursorNeurocognitiveNeuropathogenesisNoiseOlfactionOutcomePARK1 proteinPARK4 proteinPETPET ScanPET imagingPETSCANPETTParticipantPathogenesisPathologicPathway interactionsPatientsPatternPeripheralPersonsPhosphatesPhosphocreatinePhosphorousPhosphorusPhosphorylcreatinePhysiopathologyPlateletsPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessPublishingRad.-PETRegulationReportingResolutionRespirationRespiration DisordersRespiratory ChainRespiratory DisorderRiskRoleSNCASNCA proteinSignal TransductionSignal Transduction SystemsSignalingSkinSleep DisordersSmellSmell PerceptionSystemTestingThrombocytesTimea-syna-synucleinalpha synucleinalpha synuclein genealphaSP22amyloid pathologyasynbiologicbiological signal transductionbrain cellbrain visualizationbreathing disordercognitive dysfunctioncognitive functioncognitive losscognitive performancecohortdevelopmentalfluorodeoxyglucose PETfluorodeoxyglucose positron emission tomographyimage-based methodimagingimaging methodimaging modalityin vivoinorganic phosphatelongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designmitochondrialmitochondrial dysfunctionmodel of animalmulti-modal neuro-imagingmultimodal neuroimagingnecropsyneural imagingneuro-imagingneurocognitive testneurodegenerative dementianeuroimagingneurological imagingneuroprotectionneuroprotectivenon A-beta component of AD amyloidnon A4 component of amyloid precursorodor perceptionolfactory perceptionpathophysiologypathwaypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortemprimary degenerative dementiaradioligandresolutionsrespiratoryrespiratory dysfunctionrespiratory mechanismsenile dementia of the Alzheimer typesleep diseasessleep dysfunctionsleep illnesssleep problemsocial rolesynucleinopathytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targetα synuclein geneα-synα-synuclein
Description preview
PROJECT SUMMARY
Bioenergetic dysfunction is likely an early, critical component of neuropathogenesis of the second-most common
neurodegenerative dementia, Dementia with Lewy Bodies (DLB). However, it has been difficult to elucidate the specific
patterns and mechanisms of bioenergetic dysfunction, such as mitochondrial respiratory dysfunction,…
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