grant
Brain-gut interactions regulating stress-related gut inflammation and barrier permeability
Organization NEW YORK UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Sept 2023Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026ACTH-Releasing FactorAblationAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAujeszky's Disease VirusAujeszkys Disease VirusBacterial ToxinsBehaviorBehavioralBiologicalBlood leukocyteBody TissuesBrainBrain Nervous SystemBrain imagingBrain regionCNS Nervous SystemCRF-41CausalityCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous SystemChronicChronic stressCirculationColonColonic inflammationCommunicationCorticoliberinCorticotropin-Releasing FactorCorticotropin-Releasing Factor-41Corticotropin-Releasing HormoneCorticotropin-Releasing Hormone-41DiseaseDisorderDopamine-beta-monooxygenaseDysfunctionEmotionalEncephalonEndotoxemiaEndotoxinsEnteralEntericEnteric Nervous SystemEnvironmentEtiologyExhibitsFemaleFiberFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional Gastrointestinal DisordersFunctional disorderGastrointestinal DiseasesGenesGeneticGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHerpesvirus 1 (alpha), SuidHerpesvirus SuisHumanHypothalamic structureHypothalamusImmunologyInflammationInflammatoryIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal LeakageIntestinal permeabilityIntestinesIntracellular Communication and SignalingIrritable Bowel SyndromeIrritable ColonLeaky GutLeukocytesLeukocytes Reticuloendothelial SystemLinkMajor Depressive DisorderMapsMarrow leukocyteMediatingMental DepressionMental disordersMental health disordersMiceMice MammalsModelingModern ManMucous ColitisMurineMusNerve CellsNerve UnitNeural CellNeural PathwaysNeuraxisNeurocyteNeuroimmuneNeuronsNeurosciencesOccluding JunctionsParaventricular Hypothalamic NucleusPathway interactionsPeripheralPermeabilityPhenotypePhotometryPhysiopathologyProcessPseudorabies virusPsychiatric DiseasePsychiatric DisorderPsychologic StressPsychological StressPsychosocial StressReportingRisk FactorsRodent ModelSensorySeveritiesSignal TransductionSignal Transduction SystemsSignalingStressSuid Herpesvirus 1Surrogate MarkersSwine Herpesvirus 1SympathectomySympathetic DenervationSymptomsT-CellsT-LymphocyteTechniquesTight JunctionsTissuesTracerViralWhite Blood CellsWhite CellWild Type MouseZonula Occludensafferent nerveavoidance behaviorbacteria in the gutbiologicbiological signal transductionbowelbowel inflammationbrain visualizationcausationclinical depressionco-morbidco-morbiditycomorbiditycorticotropin releasing hormonedepressiondepressive behaviordetection platformdetection systemdisease causationdopamine beta hydroxylasedopamine β-hydroxylaseexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygastrointestinal disordergene manipulationgenetic manipulationgenetically manipulategenetically perturbgut bacteriagut inflammationgut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghypothalamicinflamed bowelinflamed coloninflamed gutinflamed intestineintestinal barrierintestinal inflammationintestinal mucosal barriermad itch virusmajor depressionmajor depression disordermalemental illnessmigrationneuronalparaventricular nucleuspathophysiologypathwaypsychiatric illnesspsychological disordersensory nervesocialsocial defeatspastic colonstress related disordersurrogate bio-markerssurrogate biomarkerssystemic inflammationsystemic inflammatory responsethymus derived lymphocytewhite blood cellwhite blood corpusclewildtype mouse♀♂
Description preview
Project Summary
Chronic psychosocial stress is a major risk factor for functional gastrointestinal disorders, such as irritable
bowel syndrome (IBS). Notably, there is high co-morbidity between IBS and stress-related psychiatric
disorders such as major depressive disorder (MDD), with IBS and MDD representing two of the most prevalent
and…
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