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Brain-based Mechanisms of Emotion Regulation in Aging and Mood Disorders
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 15 Dec 2020Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAffectAffectiveAffective DisordersAgeAgingAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAssayAttentionAttenuatedBehaviorBioassayBiological AssayBipolar Affective PsychosisBipolar DisorderBrainBrain Nervous SystemClinicalCognitionCognitiveCognitive deficitsComplexCoping SkillsDepressive SyndromesDepressive disorderDevelopmentDiagnosticDisablingDisease remissionElderlyEmotionalEmotional well beingEmotionsEncephalonEnrollmentFeels wellGoalsImpairmentInterventionLearningMaintenanceMajor Depressive DisorderManic-Depressive PsychosisMapsMeasuresMediatingMemoryMental DepressionMental disordersMental health disordersMood DisordersMoodsNIMHNational Institute of Mental HealthNegative ValenceNormal mental conditionNormal mental stateNormal psycheOnset of illnessOutcomePatient Self-ReportPatientsPatternPerformancePersonal SatisfactionProcessPsychiatric DiseasePsychiatric DisorderPsychological Well BeingRDoCRecurrenceRecurrentRelapseRemissionReportingResearch Domain CriteriaRestRiskSamplingSelf-ReportSense of well-beingServicesSocial FunctioningStimulusStrategic PlanningStructureSymptomsThinkingWell in selfWorkadulthoodadvanced ageage associatedage associated alterationsage associated changesage associated differenceage based differenceage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent differenceage dependent variationage differenceage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related differenceage related variationage specificage specific alterationsage specific changesage specific differenceaged brainagesaging associated alterationsaging associated changesaging brainaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageamygdaloid nuclear complexattentional biasattenuateattenuatesbiological sex as a modifierbipolar affective disorderbipolar diseasebipolar illnessbipolar mood disorderbrain basedchanges with ageclinical depressionclinical relevanceclinically relevantcognitive controlcognitive defectscoping strategycritical perioddepressiondesigndesigningdevelopmentaldiffer by agedifference across agedifference in agedisease onsetdisorder onsetemotion regulationemotional experienceemotional regulationemotional wellbeingemotional wellnessenrollexecutive controlexecutive functionflexibilityflexiblefunction sociallyfunctional disabilityfunctioning socialgeriatricheuristicsimprovedintervention designlate in lifelate lifelife spanlifespanmajor depressionmajor depression disordermanic depressive disordermanic depressive illnessmental illnessmental well-beingmental wellbeingmental wellnessmid lifemid-lifemiddle agemiddle agedmidlifenegative affectnegative affectivitynetwork dysfunctionnovelolder adultolder adulthoodperformance based assessmentsperformance based measurementperformance based measurespsychiatric illnesspsychological disorderpsychological wellbeingpsychological wellnessresistance to therapyresistant to therapyself wellnesssenior citizensense of wellbeingsex as a biological factorsex as a biological measuresex as a biological risk factorsex as a biological variablesex as a biological variancesex as a biologically significant variablesex as a fundamental variablesocialsocial defectssocial deficitssocial disorderssocial dysfunctiontherapeutic resistancetherapy designtherapy resistantthoughtstraittreatment designtreatment resistancevariation by agewell-beingwellbeingwhite matter change
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Description preview
PROJECT SUMMARY
Effective emotion regulation (ER) requires the ability to flexibly and dynamically respond to affectively-valenced
stimuli in the service of goal-directed behaviors. Patients with major mood disorders, including bipolar disorder
(BD) and major depressive disorder (MDD) are characterized by brain-based abnormalities in affective…
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