grant
BMP2/6 ligand formation and function in development and iron homeostasis
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Feb 2026Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAutoregulationBMP-2BMP-2ABMP-5BMP-6BMP2BMP2 geneBMP2A GeneBMP4BMP5BMP5 geneBMP6BMP6 geneBMP7BMP7 geneBiological FunctionBiological ProcessBody TissuesBone Morphogenetic Protein 2 GeneBone Morphogenetic Protein 2A GeneBone Morphogenetic Protein GeneBone Morphogenetic ProteinsCell Communication and SignalingCell Culture SystemCell SignalingCell secretionCellular SecretionChimeraChimera organismDNA mutationDevelopmentDevelopmental BiologyDimerizationElementsEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEndocrine Gland SecretionEndothelial CellsEquilibriumFe elementFe overloadFutureGeneHomologGenerationsGenetic ChangeGenetic defectGenetic mutationGoalsHepatic CellsHepatic Parenchymal CellHepatocyteHepc peptideHereditary DiseaseHereditary hemochromatosisHomeostasisHomologHomologous GeneHomologueHormonesHumanImpairmentIn VitroInborn Genetic DiseasesIndividualInherited disorderIntracellular Communication and SignalingIronIron Metabolism DisordersIron OverloadKI miceKO miceKnock-in MouseKnock-out MiceKnockout MiceLigandsLinkLiverLiver CellsMediatorMiceMice MammalsModern ManMorphogenesisMurineMusMutant Strains MiceMutationNull MouseNutrientOP1OrganOsteogenic Protein 1PatternPhenotypePhysiological HomeostasisPlayProcessProductionProtein DimerizationProteinsProteolytic ClippingProteolytic ProcessingReceptor ProteinRegulationRoleSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling MoleculeSignaling Pathway GeneSignaling ProteinSiteStructural ModelsTestingTissuesVG1-Related SequenceVGR1 GeneWorkXenopusXenopus sp.adulthoodbalancebalance functionbiological signal transductionbone morphogenetic protein 2bone morphogenetic protein 5bone morphogenetic protein 6bone morphogenetic protein 7bone morphogenic proteincell fate specificationchimerasclawed frogdevelopmentaldimerextracellulargenome mutationhepatic body systemhepatic organ systemhepcidinhereditary disorderheritable disorderin vivoinborn errorinherited diseasesinherited genetic diseaseinherited genetic disorderinsightiron disorderknockin micemorphogenetic processmouse mutantmutantnovelpreventpreventingprotein expressionprotein functionreceptorsocial roletraffickingvgr-1 protein
Description preview
ABSTRACT
Bone morphogenetic proteins (BMPs) play critical roles in development and adult tissue homeostasis. Class I
(BMP2 and 4) and class II (BMP5-7) BMPs are the dominant players in specifying cell fate, embryonic patterning
and organ morphogenesis. We previously showed that liver endothelial cell (LEC)-derived BMP2 and BMP6 also
have a key…
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