grant
BLRD Research Career Scientist Award Application
Organization JAMES A. HALEY VA MEDICAL CENTERLocation TAMPA, UNITED STATESPosted 1 Apr 2018Deadline 31 Mar 2032
VANIHUS FederalResearch GrantFY202565 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAAASABCD-3AchievementAchievement AttainmentAcquired brain injuryAddressAgeAged 65 and OverAgingAmerican Association for the Advancement of ScienceAnimal Disease ModelsAnimal ModelAnimal Models and Related StudiesAreaAstrocytesAstrocytusAstrogliaAwardBasic ResearchBasic ScienceBiological FunctionBiological ProcessBrainBrain InjuriesBrain Nervous SystemC3XkineCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCX(3)C proteinCX3CL1CX3CL1 geneCXC3CXC3CCessation of lifeCharacteristicsChemokine (C-X3-C Motif) Ligand 1Chemotactic CytokinesClinicalClinical SciencesCognitive DisturbanceCognitive ImpairmentCognitive agingCognitive declineCognitive deficitsCognitive function abnormalCollaborationsCommon Rat StrainsComplexDA NeuronDNA TherapyDataData SetDeathDegenerative Neurologic DisordersDisciplineDiseaseDisorderDisturbance in cognitionDopamine neuronEncephalonEnergy ExpenditureEnergy MetabolismFKN proteinFractalkineFunctional impairmentFundingGene Transfer ClinicalGenetic InterventionGliaGlial CellsGoalsHeadHealthHealth Care SystemsHomologous Chemotactic CytokinesHortega cellHospital AdmissionHospitalizationHospitalsImpaired cognitionInflammasomeInflammationInflammatoryInjuryInnate Immune SystemIntercrinesInterventionIntranasal AdministrationIntranasal Drug AdministrationInvestigatorsKnock-outKnockoutKolliker's reticulumLegal patentLinkMemory LossMicrogliaModelingMolecularNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic DeficitNeurologic Degenerative ConditionsNeuronsNon-neuronal cellNonneuronal cellOlder PopulationOutcomeParalysis AgitansParkinsonParkinson DiseasePatentsPathway interactionsPhenotypePopulationPrimary ParkinsonismProductivityProteomicsRatRats MammalsRattusReceptor ProteinResearchResearch PersonnelResearchersRiskRisk FactorsRoleSCYD1SIS cytokinesScientistSmall Inducible Cytokine D1T cell regulationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTBI recoveryTauopathiesTherapeuticTherapeutic EffectTherapeutic InterventionTimeTraumatic Brain Injury recoveryVeteransVulnerable PopulationsWorkabove age 65after age 65age 65 and greaterage 65 and olderage 65 or olderageage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage induced alterationsage induced changesage of 65 years onwardage related alterationsage related changesage specific alterationsage specific changesagedaged 65 and greateraged 65+aged animalaged animalsaged brainaged ≥65agesaging associated alterationsaging associated changesaging brainaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageanimal old ageastrocytic gliabrain damagebrain-injuredbuild resiliencebuild resiliencycare seekingcareerchanges with agechemoattractant cytokinechemokineco-morbidco-morbiditycognitive defectscognitive dysfunctioncognitive functioncognitive losscomorbiditycytokinedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdetection of nutrientdevelop resiliencedevelop resiliencydisease modeldisorder modeldopaminergic neuronelderly animalenhance resilienceenhance resiliencyexamination questionsfacilitate resiliencegene repair therapygene therapygene-based therapygenetic therapygenome profilinggenomic profilinggenomic therapygitter cellhuman old age (65+)improve resilienceimprove resiliencyimprovedincrease resilienceincrease resiliencyinjuriesintervention designintervention therapyjuvenile animallong-term sequelaemeetingmeetingsmemory declinemesogliamicroglial cellmicrogliocytemodel of animalmotor diseasemotor disordermotor dysfunctionnerve cementneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneuronalneuropathologic tauneuropathological tauneuroprotectionneuroprotectivenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynutrient sensingold animalsolder groupsolder individualsolder personover 65 yearspathwayperception of nutrientsperivascular glial cellprogenitor derived exosomesprogenitor exosomesprogramspromote resiliencepromote resiliencyreceptorrecovery after TBIrecovery after traumatic brain injuryresilienceresilience developmentresilientscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cell derived exosomesstem cell exosomessynucleintau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytherapy designthymus derived lymphocytetooltranscriptome profilingtranscriptomic profilingtreatment designunpublished worksvulnerable groupvulnerable individualvulnerable peopleyoung animal≥65 years
Description preview
Dr. Paula C. Bickford is currently a Senior Research Career Scientist at the James A. Haley VA
Hospital in Tampa, FL. She continues to be a productive and collaborative VA scientist. She was
awarded the 2023 William S. Middleton Award reflecting her significant achievements as a VA scientist.
Her research focus is in the area of aging and…
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