grant
BLRD Research Career Scientist Award Application
Organization SOUTH TEXAS VETERANS HEALTH CARE SYSTEMLocation SAN ANTONIO, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
VANIHUS FederalResearch GrantFY20252-ketoglutarate2-oxoglutarate21+ years old3'5'-cyclic ester of AMPAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AdultAdult HumanAmerican Society of HematologyAnti-CD20 AntibodyAntigen PresentationAreaArmed Forces PersonnelAvian Myelocytomatosis Viral Oncogene HomologAwardB blood cellsB cellB cell malignancyB cell receptorB cellsB lymphoid malignancyB lymphomaB-Cell Antigen ReceptorB-Cell LymphomasB-CellsB-LymphocytesB-cellBAL geneBAL proteinBasal Transcription FactorBasal transcription factor genesBiologyBloodBlood CirculationBlood Reticuloendothelial SystemBloodstreamBone MarrowBone Marrow Reticuloendothelial SystemC2B8 Monoclonal AntibodyCancer BiologyCancer GenesCancer-Promoting GeneCancersCell BodyCell Communication and SignalingCell SignalingCellsCheckpoint inhibitorChemicalsChromosomal dislocationChromosomal translocationChronic Granulocytic LeukemiaChronic Myelocytic LeukemiaChronic Myelogenous LeukemiaChronic Myeloid LeukemiaClinicClinicalClinical TrialsCollectionCredentialingCyclic AMPDF/HCCDLBCLDNADNA MethylationDNA mutationDana-Farber Cancer InstituteDeoxyribonucleic AcidDevelopmentDiagnosisDiffuse Large B-Cell LymphomaDiseaseDisorderDoctor of PhilosophyEarly-Stage Clinical TrialsEnrollmentEnvironmental ExposureEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFGF ReceptorsFGF-RFGFRFacultyFeedbackFibroblast Growth Factor Receptor FamilyFibroblast Growth Factor ReceptorsFoundationsFundingGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranslocationGenetic defectGenetic mutationGerminoblastic SarcomaGerminoblastomaHealthHealth Care SystemsHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHistonesHospitalsHypermethylationImmune checkpoint inhibitorImmunoglobulin Enhancer-Binding ProteinIn VitroIncidenceIntermediary MetabolismIntracellular Communication and SignalingInvestigationInvestmentsIsocitrate DehydrogenaseKnowledgeLaboratoriesLinkLondonLymph Node Reticuloendothelial SystemLymph node properLymphatic cellLymphatic nodesLymphocyteLymphocyticLymphomaLymphoma cellLymphomagenesisMYC geneMabTheraMalignant CellMalignant Hematologic NeoplasmMalignant LymphomaMalignant NeoplasmsMalignant TumorMapsMature B-CellMature B-LymphocyteMediatorMedicineMentorsMentorshipMetabolic ProcessesMetabolismMicroRNAsMilitaryMilitary PersonnelMitochondriaMolecularMutationMyeloid DiseaseMyeloid MalignancyMyeloid NeoplasmMyeloid TumorMyeloproliferative DisordersMyeloproliferative TumorsMyeloproliferative diseaseNF-kBNF-kappa BNF-kappaBNFKBNamesNatureNon-Polyadenylated RNANuclear Factor kappa BNuclear Transcription Factor NF-kBOncogenesOncogenicOrganOutcomePARP9PARP9 genePDE4 enzymePDE4BPDase IVPaperPathogenesisPathway interactionsPatientsPh 1 ChromosomePh.D.Ph1 ChromosomePhDPhasePhase 1 Clinical TrialsPhase I Clinical TrialsPhiladelphia ChromosomePopulationPostdocPostdoctoral FellowPrivatizationProductivityPropertyPublicationsPublishingRNARNA Gene ProductsRNA methylationRandomization trialRandomizedReportingResearchResearch ActivityResearch AssociateReticulolymphosarcomaRibonucleic AcidRituxanRoleSafetyScientific PublicationScientistSignal TransductionSignal Transduction SystemsSignalingSiteSomatic MutationSouth TexasSpleenSpleen Reticuloendothelial SystemSupplementationSyndromeSystemTestingTexasTimeTranscript Expression AnalysesTranscript Expression AnalysisTranscription Factor NF-kBTranscription Factor Proto-OncogeneTranscription factor genesTransferaseTransferase GeneTransforming GenesTranslatingTumor BurdenTumor ImmunityTumor LoadUniversitiesVeteransWorkadenosine 3'5' monophosphateadulthoodalpha ketoglutarateanalyze gene expressionanti-CD20anti-canceranti-tumor immunityantitumor immunitybiological signal transductioncAMPcancer cellcancer immunitycancer microenvironmentcancer typecareerchemotherapychromosome dislocationchromosome translocationclinical applicabilityclinical applicationclinical heterogeneityclinical translationclinically translatablecohortdemethylationdesigndesigningdevelopmentaldifferential expressiondifferentially expresseddisease heterogeneityenrollepigeneticallyepigenomefallsgene expression analysisgene expression assaygenome mutationgenome scalegenome-widegenomewideimmune check point inhibitorimprovedin vivoinhibitorkappa B Enhancer Binding Proteinlarge cell Diffuse non-Hodgkin's lymphomaleukemialoss of function mutationlymph celllymph glandlymph nodeslymphnodesmalignancymedical collegemedical schoolsmeetingmeetingsmiRNAmilitary populationmitochondrialmitochondrial metabolismmyc Oncogenesmyeloproliferative neoplasmnamenamednamingneoplasm/cancernotchnotch proteinnotch receptorsnovelnuclear factor kappa betaoverexpressoverexpressionpathwayphase 2 trialphase I protocolphase II trialphosphodiesterase 4phosphodiesterase 4Bphosphodiesterase IVpost-docpost-doctoralpost-doctoral traineepost-doctoral trainingpre-clinicalpreclinicalprogramsrandomisationrandomizationrandomized trialrandomly assignedrecruitresearch associatesrituximabschool of medicinesocial rolesomatic varianttherapeutic targettranscription factortranscriptional differencestranscriptional profilingtumor microenvironmenttype 4 cyclic nucleotide phosphodiesteraseα-ketoglutarateα-oxoglutarateαKG
Description preview
The overarching objective of the Aguiar laboratory is to improve our understanding of cancer
biology, in particular the molecular and cellular basis of B cell lymphomas development and
progression with the intent of translating these discoveries into clinical activities. The Aguiar
laboratory uses in vitro and in vivo systems, in genome-wide or…
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