grant
Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 16 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026(TNF)-α2019 novel corona virus2019 novel coronavirus2019-nCoV21+ years oldABCD-3AdultAdult HumanAmericanAnxietyAreaAttentionB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BBB disruptionBBB permeabilizationBBB permeableBCDFBDNFBSF-2BSF2Biological MarkersBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood monocyteBlood-Brain BarrierBody SystemBrainBrain Nervous SystemBrain imagingBrain-Derived Neurotrophic FactorC3XkineCCL2CCL2 geneCD14CD14 geneCD16CD16BCD183CKR-L2CMKAR3CNS Nervous SystemCOVID infected patientCOVID patientCOVID positive patientCOVID-19COVID-19 infected patientCOVID-19 patientCOVID-19 positive patientCOVID-19 virusCOVID19 patientCOVID19 positive patientCOVID19 virusCRG-2CV-19CX(3)C proteinCX3CL1CX3CL1 geneCXC3CXC3CCXCL10CXCL10 geneCXCR3CXCR3 geneCachectinCell BodyCell LocomotionCell MigrationCell MovementCell Surface ProteinsCellsCellular MigrationCellular MotilityCentral Nervous SystemChemokine (C-X-C Motif) Receptor 3Chemokine (C-X3-C Motif) Ligand 1Chemokine, CC Motif, Ligand 2Chemotactic CytokinesChronicChronic DiseaseChronic Fatigue DisorderChronic Fatigue SyndromeChronic Fatigue and Immune Dysfunction SyndromeChronic IllnessChronic Infectious Mononucleosis-Like SyndromeCoV-2CoV2CognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCohort StudiesComplexControl GroupsCoronavirus Infectious Disease 2019Depressed moodDisabling conditionDisabling health conditionDiseaseDisorderDisturbance in cognitionEmotional DepressionEncephalonEndotheliumExertionExhibitsFCGR3BFCGR3B geneFKN proteinFatigueFc Receptor III-1Fc gamma IIIb receptorFc-Gamma RIII-BetaFc-Gamma RIIIBFcRIIIBFractalkineFundingG Protein-Coupled Receptor 9GPR9Glymphatic impairmentGlymphatic system dysfunctionGlymphatic system impairmentHIV associated neurological diseaseHIV associated neurological disorderHPGFHemato-Encephalic BarrierHepatocyte-Stimulating FactorHomologous Chemotactic CytokinesHybridoma Growth FactorHydrogen OxideIFI10IFN-Gamma-Inducing Factor GeneIFN-beta 2IFN-gamma-Inducing FactorIFNB2IGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-18IL-18 GeneIL-1gIL-1g GeneIL-6IL18IL18 ProteinIL18 geneIL1F4IL1F4 GeneIL6 ProteinINP10IP-10IP10IP10 ReceptorIP10-Mig receptorIP10-RIQ DeficitIgG Fc Receptor IIIBIllness impactImageImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmunesImmunologic SubtypingImmunophenotypingImpaired cognitionIndividualInfectionInfiltrationInflammationInflammatoryInfrastructureIntercrinesInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-6Lack of EnergyLinkLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019Low Affinity IgG Fc Receptor IIIBLow Affinity Immunoglobulin Gamma Fc Region Receptor III-BMCAFMCP-1MCP1ME/CFSMGC12320MGC12320 GeneMGI-2MOB-1MR ImagingMR TomographyMRIMRIsMacrophage-Derived TNFMagnetic Resonance ImagingMalaiseMarrow monocyteMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMental HealthMental HygieneMig ReceptorMig-RMigRMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMonocyte-Derived TNFMoodsMyalgic EncephalomyelitisMyeloid Differentiation-Inducing ProteinNMR ImagingNMR TomographyNational Institutes of HealthNerve CellsNerve UnitNeural CellNeuraxisNeurocognitiveNeurocognitive DeficitNeurocyteNeuronsNuclear Magnetic Resonance ImagingOrgan SystemPBMCParticipantPathway interactionsPatientsPeripheral Blood Mononuclear CellPhasePlasmacytoma Growth FactorPostviral Fatigue SyndromePsychological HealthReportingResidualResidual stateRoleRoyal Free DiseaseSARSSARS corona virus 2SARS coronavirus diseaseSARS-CO-V2SARS-COVID-2SARS-CoV diseaseSARS-CoV-2SARS-CoV-2 infected patientSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SCYA2SCYB10SCYD1SIS cytokinesSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory SyndromeSevere Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV diseaseSevere Acute Respiratory Syndrome coronavirus diseaseSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Small Inducible Cytokine A2Small Inducible Cytokine D1SurfaceSymptomsTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTechniquesTherapeuticTherapeutic InterventionTumor Necrosis FactorTumor Necrosis Factor-alphaUnited States National Institutes of HealthVEGFVEGFsVascular Endothelial Growth FactorsViral DiseasesVirus DiseasesWaterWuhan coronavirusZeugmatographyacute COVID-19acute SARS-CoV-2 infectionacute infectionacute phase of COVID-19acute phase of SARS-CoV-2 infectionadulthoodarterial spin labelingarterial spin taggingbio-markersbiologic markerbiomarkerblood-brain barrier disruptionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier disruptionbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain fogbrain visualizationcell motilitychemoattractant cytokinechemokinechronic COVIDchronic COVID-19chronic disorderchronic novel coronavirus disease 2019cognitive disabilitycognitive dysfunctioncognitive functioncognitive losscognitively disabledcohortcohort research studycohort surveycoronavirus disease 2019coronavirus disease 2019 infected patientcoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19coronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcytokinedepresseddepression symptomdepressivedepressive symptomsexperiencefunctional restorationgIP-10glymphatic dysfunctionhCoV19imaginginnovateinnovationinnovativeintelligence quotient deficitinterferon beta 2intervention therapylong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019migrationmild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmonocytenCoV2neural inflammationneuro-AIDSneuro-HIVneuroAIDSneuroHIVneurocognitive declineneurocognitive impairmentneuroinflammationneuroinflammatoryneuronalneuropsychiatricneuropsychiatrynovelpathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2perceived stressperception of stresspersistent COVID-19post COVID syndromepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19post-pandemicpre-pandemicprolonged COVID-19 symptomsresponserestore functionrestore functionalityrestore lost functionruminateruminationruminativesadnessself-reported stresssevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsmall moleculesocial rolestress perceptiontherapeutic agent developmenttherapeutic developmenttraffickingviral infectionvirus infectionvirus-induced disease
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PROJECT SUMMARY/ABSTRACT
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is a long-term disabling condition with a wide
range of symptoms, often triggered by acute infection. The CDC estimates that in 2022, over 3.5 million
Americans are living with ME/CFS, and this number continues to increase as many Long COVID patients develop…
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