grant
BIOPHYSICAL CUES SHAPING MACROPHAGE AND T-CELL FUNCTIONS
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20252-dimensional3-D3-Dimensional3DAD dementiaASCVDAdoptedAdoptive Cell TransfersAlginatesAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaArthritisAssayAtherosclerosisAtherosclerotic Cardiovascular DiseaseBasal Transcription FactorBasal transcription factor genesBasement membraneBehaviorBioassayBiochemicalBiological AssayBiophysicsBody TissuesBreast NeoplasmsBreast TumorsCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCell BodyCell CommunicationCell FunctionCell InteractionCell Membrane LipidsCell PhysiologyCell ProcessCell ShapeCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeCharacteristicsCholesterolClinicalComputational toolkitComputer AnalysisCuesDataDeathDependenceDiabetes MellitusDiseaseDisease ProgressionDisorderDrugsECMElasticityEncapsulatedEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionExhibitsExtracellular MatrixFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic TranscriptionHarvestHeterogeneityHomingHydrogelsImageImmuneImmune mediated therapyImmune responseImmune signalingImmunesImmunofluorescenceImmunofluorescence ImmunologicImmunologic SubtypingImmunologically Directed TherapyImmunologyImmunophenotypingImmunotherapyInflammationInflammation MediatorsInflammatoryLiquid substanceMacrophageMalignant CellMalignant NeoplasmsMalignant TumorMammary CancerMammary NeoplasmsMeasurementMechanicsMedicationMembrane LipidsMiceMice MammalsModificationMonitorMorphologyMurineMusMyeloid CellsMφNuclear TranslocationPD 1PD-1PD1PathologyPharmaceutical PreparationsPhenotypePrimary Senile Degenerative DementiaPropertyRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinResearchResolutionRoleSeriesShapesSignaling MoleculeSolidSubcellular ProcessSurfaceSystemT-CellsT-LymphocyteT8 CellsT8 LymphocytesTimeTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumor-associated macrophagesVHHVHH antibodyViscosityadoptive cell therapyadoptive cellular therapyadvanced diseaseadvanced illnessanti-cancer immunotherapyanticancer immunotherapyarthriticatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencescamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincancer cellcancer immunotherapycancer infiltrating T cellscancer microenvironmentcancer progressioncell behaviorcell killingcellular behaviorcomputational analysescomputational analysiscomputational toolboxcomputational toolscomputational toolsetcomputer analysescomputerized toolsconfocal imagingcytokinediabetesdrug/agentepigeneticallyexhaustionfightingflow cytophotometryfluidglobal healthhost responsehuman diseaseimagingimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimmunotherapy for cancerimmunotherapy of cancerin vivoinflammatory mediatorinflammatory modulationinsightliquidmachine learned algorithmmachine learning algorithmmachine learning based algorithmmalignancymammary tumormechanicmechanicalnanobodiesnanobodyneoplasm progressionneoplasm/cancerneoplastic progressionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyphysical propertyprimary degenerative dementiaprogrammed cell death 1programmed cell death protein 1programmed death 1programsreceptorreconstitutereconstitutionresolutionsresponserestraintscRNA sequencingscRNA-seqsdAbsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell transcriptomic profilingsingle domain antibodiessingle-cell RNA sequencingsle2small molecular inhibitorsmall molecule inhibitorsocial rolespatial and temporalspatial temporalspatiotemporalspheroidssystemic lupus erythematosus susceptibility 2three dimensionalthymus derived lymphocytetooltraffickingtranscription factortranscriptome sequencingtranscriptomic sequencingtranslational impacttumortumor infiltrating T cellstumor microenvironmenttumor progressiontwo-dimensionalunsupervised learningunsupervised machine learningvariable heavy chain antibodyviscoelasticity
Description preview
Project summary. Inflammation underlies majority of human diseases including diabetes, atherosclerosis, and
cancer. These diseases are responsible for majority of deaths and represent substantial global health burden.
Macrophages and T-cells, subsets of immune cells, have emerged as key mediators of inflammation. The role
of biochemical cues in…
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