grant
Bioorthogonal temporospatial tools
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Jul 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAccelerationArchitectureBiologicalBiotechBiotechnologyBody TissuesCell BodyCell Communication and SignalingCell SignalingCellsChemicalsChemistryClosure by LigationDetectionDevelopmentEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventGene ExpressionGenerationsGoalsGrainHistoryHybridsIndividualIntracellular Communication and SignalingInvestigationKineticsLigationMemoryMethodsMolecularMolecular Dynamics SimulationMolecular Hybridization Molecular BiologyNucleic Acid HybridizationNucleic AcidsOrganismPerformancePopulationPropertyReactionRecording of previous eventsResearchSignal TransductionSignal Transduction SystemsSignalingSpecificitySpeedSynapsesSynapticSystemTimeTissuesTranslatingTranslationsVisualizationbiocompatibilitybiologicbiological signal transductionbiomaterial compatibilitydetection sensitivitydevelopmentalepigeneticallyhistoriesin vivoliving systemmolecular dynamicsmultiplexed imagingresponsescaffoldscaffoldingsuccesssynapsethree dimensionaltooltranslation
Description preview
PROJECT SUMMARY
Living systems choreograph molecular events with precise control—place, time, kinetics, and intensity
—and record memories of those occurrences in synaptic networks, gene expression, epigenetic
marks, and myriad other circuits that govern the where&when of biologic responses. Visualizing this
choreography and tracing these…
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