grant
Bioluminescent FAK Sensor and Genome-Wide CRISPR Knockout Screen to Identify Regulators of Cellular Adhesion
Organization CENTRAL MICHIGAN UNIVERSITYLocation MOUNT PLEASANT, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAdhesion PlaquesAdhesionsBCAR1BCAR1 ProteinBCAR1 geneBasal Transcription FactorBasal transcription factor genesBioinformaticsBiologicalBioluminescenceBlinkingBody TissuesBreast Cancer Anti-Estrogen Resistance 1 ProteinCKRAS proteinCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCRK-Associated SubstrateCRKASCas proteinCell AdhesionCell BodyCell Communication and SignalingCell FunctionCell LineCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell SignalingCell-Extracellular MatrixCell-Matrix Adherens JunctionsCellLineCellsCellular AdhesionCellular FunctionCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular biologyChromosome MappingClustered Regularly Interspaced Short Palindromic RepeatsComplexCustomCytoskeletal SystemCytoskeletonDiseaseDisorderECMEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEngineeringEventExtracellular MatrixFluorescence Activated Cell Sorting FractionationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsFocal Adhesion Kinase 1Focal AdhesionsFocal ContactsGene LocalizationGene MappingGene Mapping GeneticsGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGenomeGoalsGuide RNAHealthHealth BenefitHumanImmune SurveillanceImmune responseImmunologic SurveillanceImmunosurveillanceIndividualInflammationIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingKinasesKnock-outKnockoutKnowledgeLibrariesLightLinkage MappingLocomotionLogicMapsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMichiganModern ManMolecularNGS MethodNGS systemNeoplasm MetastasisPTK2 Protein Tyrosine Kinase 2PathologicPathway interactionsPhosphorylationPhosphotransferase GenePhosphotransferasesPhotoradiationPhysiologicPhysiologicalPlayPopulationProcessProtein PhosphorylationProteinsPublic HealthRNA ExpressionRegulationReporterReporter GenesResearchRoleSecondary NeoplasmSecondary TumorSeriesShort interfering RNASignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNAStrains Cell LinesStructureSubcellular ProcessTestingTherapeutic InterventionTimeTissuesTotal Human and Non-Human Gene MappingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesUniversitiesVisualizationWound Repairbiologicbiological signal transductioncancer metastasiscell biologycell motilitycell typeclustered regularly interspaced short palindromic repeats screencultured cell linecustomsdesigndesigningendogenous substrate pp120entire genomeexpression vectoreye blinkeyeblinkfocal adhesion kinasefocal adhesion protein tyrosine kinasefocal adhesion-associated protein tyrosine kinase pp125FAKfull genomegRNAgenetic mappinggenome scalegenome-widegenomewidehost responseimmune system responseimmunoresponseinnovateinnovationinnovativeinsightintervention therapyintracellular skeletonlight emissionmigrationmolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext gen sequencingnext generation sequencingnextgen sequencingnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetoverexpressoverexpressionp130 cas proteinp130CASpathwaypaxillinpeptide mimeticpeptide mimicpeptidomimeticspopulation basedresponsesensing technologysensorsensor technologysensor-based technologysiRNAsocial roletranscription factortumor cell metastasiswhole genomewound healingwound recoverywound resolution
Description preview
This project leverages a combination of bioluminescence-controlled transcription and robust genome-wide CRISPR screening, the research will map the regulation of Focal Adhesion Kinase (FAK) activity and help elucidate the complex genetic networks that govern cellular adhesion and locomotion, advancing the field of cellular biology.
The project is…
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