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Biological Signature and Safety of an Immunomodulatory Probiotic Intervention of Veterans with PTSD
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 Feb 2020Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025(TNF)-α16S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqAccelerationAddressAnionic Neutrophil-Activating PeptideAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryB cell differentiation factorB cell growth factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-1B-Cell Differentiation Factor-2B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-Cell Stimulatory Factor-2BCDFBCDF-1BCGFBCGF-1BCSF 1BSF-1BSF-2BSF1BSF2Beta Proprotein Interleukin 1BinetrakinBiologicalBiological MarkersBlood PlasmaBrainBrain Nervous SystemC-reactive proteinCNS Nervous SystemCSIFCSIF-10CachectinCentral Nervous SystemChemotactic CytokinesChemotactic Factor, Neutrophil, Monocyte-DerivedChronicClinicalCo-StimulatorCommunitiesCostimulatorCytokine Synthesis Inhibitory FactorD-Amino Acid DehydrogenaseD-Amino-Acid OxidaseDataDecision MakingDiagnosisDiseaseDisorderDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrugsEncephalonEpidermal Thymocyte Activating FactorEvaluationFreedomFrustrationFunding OpportunitiesFutureGCP-IL-8GI microbiotaGamblingGastrointestinal microbiotaGoalsGranulocyte Chemotactic Peptide-Interleukin-8Gut Epithelial PermeabilityGut HyperpermeabilityGut MucosaGut permeabilityHPGFHealthHepatocyte-Stimulating FactorHomologous Chemotactic CytokinesHumanHybridoma Growth FactorIFN-GammaIFN-beta 2IFN-gIFN-γIFNB2IFNGIFNγIL-1 betaIL-1 βIL-1-bIL-10IL-1βIL-2IL-4IL-6IL1-BetaIL1-βIL10IL10AIL1B ProteinIL1F2IL1βIL2 ProteinIL4 ProteinIL6 ProteinImmune InterferonImmunomodulationImpairmentIndividualInflammationInflammatoryIntercrinesInterferon GammaInterferon Type IIInterleukin 10 PrecursorInterleukin 1betaInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-1 betaInterleukin-10Interleukin-1βInterleukin-2Interleukin-4Interleukin-4 PrecursorInterleukin-6Interleukin-8Interleukine 2Interleukine 2 PrecursorInterleukine IIInterleukinsInterventionIntervention StrategiesIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityIntestinesIowaIraqiIrritable Bowel SyndromeIrritable ColonL rhamnosusL. rhamnosusLactobacillus casei rhamnosusLactobacillus rhamnosusLeukocyte Adhesion InhibitorLibertyLinkLymphocyte Mitogenic FactorLymphocyte Stimulatory Factor 1Lymphocyte-Derived Neutrophil-Activating PeptideMCGF-2MGI-2Macrophage-Derived Chemotactic FactorMacrophage-Derived TNFMast Cell Growth Factor-2MeasuresMediatingMedicationMental HealthMental HygieneMethodsMitogenic FactorModern ManMonocyte-Derived Neutrophil-Activating PeptideMonocyte-Derived TNFMucosal InflammationMucositisMucous ColitisMyeloid Differentiation-Inducing ProteinNational Institutes of HealthNeuraxisNeutrophil Activating PeptideNeutrophil Activation FactorNeutrophil Activation PeptideNeutrophil Chemotactic FactorOral AdministrationOral Drug AdministrationOrganismOutcomePTSDParticipantPerformancePeripheralPharmaceutical PreparationsPhasePlacebo ControlPlacebosPlasmaPlasma SerumPlasmacytoma Growth FactorPlayPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPreinterleukin 1 BetaProbioticsProceduresProcessProductionPropertyProteins, specific or class, C-reactivePsychological HealthPsychotherapyQuantitative RTPCRQuantitative Reverse Transcriptase PCRRandomizedResearchResistanceReticuloendothelial System, Serum, PlasmaRibosomal RNA GenesRiskRisk FactorsRoleSIS cytokinesSafetySeveritiesSham TreatmentStressSupplementationSymptomsT cell growth factorT-Cell Growth FactorT-Cell Growth Factor 2T-Cell Stimulating FactorTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingThymocyte Stimulating FactorTrier Social Stress TestTumor Necrosis FactorTumor Necrosis Factor-alphaUnited StatesUnited States National Institutes of HealthVeteransactive dutyactive serviceadverse consequenceadverse outcomealleviate symptomalternative treatmentameliorating symptomassociated symptombio-markersbiologicbiologic markerbiological adaptation to stressbiomarkerbowelchemoattractant cytokinechemokinechronic symptomco-morbid symptomco-occuring symptomcognitive processcohortcomorbid symptomconcurrent symptomcooccuring symptomcopingcytokinedecrease symptomdesigndesigningdextro-Amino Acid Oxidasedrug/agentefficacy trialemotion regulationemotional regulationenteric microbial communityenteric microbiotafatty acid-binding proteinsfewer symptomsfunctional improvementfunctional outcomesgastrointestinal microbial floragut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microfloraimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprove functionimprovedimproved functional outcomesinflammation markerinflammatory markerinnovateinnovationinnovativeinterferon beta 2intestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloraintraoral drug deliverylFN-Gammaliving systemmicrobiota compositionmilitary membermilitary servicemilitary veteranneuroprotectionneuroprotectivenoveloperationoperationspersistent symptomplacebo controlledpost-trauma stress disorderpost-traumatic stress symptomspost-traumatic symptomsposttrauma stress disorderposttraumatic stress symptomsposttraumatic symptomsprimary outcomeprobiotic supplementprobiotic supplementationpsychologicpsychologicalpsychosocialqRTPCRrRNA Genesrandomisationrandomizationrandomly assignedreaction; crisisreduce symptomsrelieves symptomsresistantresponseservice membersham therapysocial rolespastic colonstress reductionstress responsestress; reactionsupplementation with probioticssymptom alleviationsymptom associationsymptom comorbiditysymptom reductionsymptom reliefsymptom treatmentsymptomatic treatmentsystemic inflammationsystemic inflammatory responsetraumatic neurosistreat symptomveteran population
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Project Summary/Abstract
United States military Veterans from recent conflicts are coping with symptoms related to posttraumatic stress disorder (PTSD). Many Veterans are resistant to conventional health and mental health interventions (e.g., medication, psychotherapy), and often symptoms are not significantly improved by traditional treatments.…
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