grant
Biological drivers of sex differences in frontotemporal dementia
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD related dementiaADRDAddressAdultAdult HumanAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease therapyAlzheimer's therapyAlzheimers DementiaAmentiaAquadiolAreaAssayAtrophicAtrophyBioassayBiologicalBiological AssayBiologyBlood PlasmaBrainBrain Nervous SystemCerebrospinal FluidClinicalCognitiveCognitive agingCorpus Luteum HormoneDataDelta4-pregnene-3,20-dioneDementiaDevelopmentDifferences between sexesDiffers between sexesDimenformonDiogynDiogynetsDiseaseDisease ProgressionDisorderDysfunctionEncephalonEndocrine Gland SecretionEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogensEvaluationFTD dementiaFemaleFollicle Stimulating HormoneFollitropinFrontal Temporal DementiaFrontotemporal DementiaFunctional disorderGeneticGestationGoalsGonadal Steroid HormonesHealthHistoryHormonesImmuneImmunesIndividualIntermediary MetabolismInternationalKnowledgeLightMT-bound tauMeasuresMemoryMenopauseMetabolic ProcessesMetabolismModelingNatural HistoryNerve DegenerationNeurofibrillary TanglesNeuron DegenerationOvarianOvocyclinOvocylinPaperPatternPersonalized medical approachPersonsPhenotypePhotoradiationPhysiopathologyPlasmaPlasma SerumPositionPositioning AttributePrecision therapeuticsPregn-4-ene-3,20-dionePregnancyPregnenedionePrevalencePreventionPrimary Senile Degenerative DementiaProgesteroneProgynonProteinsProteomicsPublishingRecording of previous eventsReproductive FactorsReproductive HealthReproductive HistoryReproductive History EpidemiologyReproductive IssuesResearchReticuloendothelial System, Serum, PlasmaRiskSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSiteSymptomsSynapsesSynapticTestosteroneTherapeutic EstradiolTherapeutic EstrogenTherapeutic HormoneTherapeutic ProgesteroneTherapeutic TestosteroneTimeTrans-TestosteroneWomanWorkadulthoodagesautosomebehavioral variant FTDbehavioral variant frontotemporal degenerationbehavioral variant frontotemporal dementiabiologicbiological sexbirth controlbrain healthbvFTDcerebral spinal fluidcohortcomparing females and malescomparing women and mencomputer based predictiondementia riskdevelopmentaldisease modeldisorder modeldisparities in treatmentdisparity gapdisparity in healthequity gapfemale reproductive healthfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiagap in equitygap in inequalitygap in inequitygonadal steroidshealth disparityhistoriesindividualized approachinequality gapinequality in treatmentinequitable gapinequity gapinnovateinnovationinnovativeinsightmalemicrotubule bound taumicrotubule-bound taumutation carrierneural degenerationneural imagingneuro-imagingneurobehavioralneurodegenerationneurodegenerativeneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurofilamentneuroimagingneurological degenerationneurological imagingneuronal degenerationnovelpathophysiologypersonalized approachprecision approachprecision therapiesprecision treatmentpredictive modelingprimary degenerative dementiaprimary outcomeprognosticationprospectiveproteomic signaturereproductivereproductive health among femalesreproductive health among womenreproductive health in femalesreproductive health in womenresilienceresilientrisk factor for dementiarisk for dementiasenile dementia of the Alzheimer typesexsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencesspinal fluidsynapsetailored approachtangletautau Proteinstau factortooltreatment disparitytreatment inequalitytreatment inequitywomen compared to menwomen compared with menwomen versus menwomen vs. menwomen's reproductive healthτ Proteins♀♂
Description preview
ABSTRACT
Dementia prevalence and disease course differs by sex. Yet, despite being the leading cause of young onset
dementia, very little is known about sex differences in frontotemporal dementia (FTD). Our accumulating data
suggest females with FTD show patterns of “cognitive resilience” consistent with delayed symptom
manifestation, despite…
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