grant
Bioinformatics and Computational Biology Core
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD related dementiaADRDAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAutopsyBioinformaticsBioinformatics coreBioinformatics research coreBioinformatics resource coreBiologic ModelsBiological MarkersBiological ModelsBlood PlasmaBrainBrain Nervous SystemCell LineCell modelCellLineCellular modelClinical MarkersCo-cultureCocultivationCocultureCoculture TechniquesCohort StudiesCollaborationsComplementComplement ProteinsComputational BiologyConcurrent StudiesDataData AnalysesData AnalysisData Management CoreData SetDementiaDevelopmentDiathesisDiseaseDisease susceptibilityDisorderDysfunctionEcologic SystemsEcological SystemsEcosystemEncephalonEnsureFAIR dataFAIR guiding principlesFAIR principlesFindable, Accessible, Interoperable and Re-usableFindable, Accessible, Interoperable, and ReusableFunctional disorderFundingFutureGeneticGoalsHumanIndividualIntervention StrategiesKnowledge PortalKnowledge base PortalKnowledgebase PortalLinkLipidsMapsMiceMice MammalsModalityModel SystemModelingModern ManMolecularMolecular FingerprintingMolecular ProfilingMolecular TargetMultiomic DataMurineMusOutcomePhenotypePhysiologicPhysiologicalPhysiopathologyPlasmaPlasma SerumPopulation HeterogeneityPrecision therapeuticsPrimary Senile Degenerative DementiaPrimatesPrimates MammalsProcessProteinsProteomicsReproducibilityResearchReticuloendothelial System, Serum, PlasmaRiskStandardizationStrains Cell LinesSystemTestingThe Jackson LaboratoryTherapeutic EffectValidationWorkalzheimer modelanalytical methodbio-markersbiologic markerbiomarkerbrain basedbrain tissuecell typeclinical biomarkersclinically useful biomarkerscohortcomplementationcomputer biologycultured cell linedata integrationdata interpretationdata management and coordinating centerdata management centerdata-driven modeldevelopmentaldisease subgroupsdisease subtypedisorder subtypediverse populationsheterogeneous populationhuman datahuman population studyhuman studyliability to diseaselipidomicsmicrophysiologic modelmicrophysiologic platformmicrophysiologic systemmicrophysiology modelmicrophysiology platformmicrophysiology systemmolecular profilemolecular scalemolecular signaturemulti-modal datamulti-modal datasetsmultimodal datamultimodal datasetsmultiomicsmultiple omic datamultiple omicsnecropsynovelpanomicspathophysiologyphenotypic datapopulation diversitypopulation stratificationpostmortempre-clinical efficacypre-clinical safetyprecision medicineprecision therapiesprecision treatmentprecision-based medicinepreclinical efficacypreclinical safetyprimary degenerative dementiaresponseresponse to therapyresponse to treatmentrisk stratificationsenile dementia of the Alzheimer typestratify risktargeted biomarkertherapeutic candidatetherapeutic responsetherapy responsetreatment responsetreatment responsivenessvalidations
Description preview
PROJECT SUMMARY/ABSTRACT BIOINFORMATICS AND COMPUTATIONAL BIOLOGY CORE
The Bioinformatics and Computational Biology (BCB) Core will develop and employ analytical methods to assess
and align microphysiological systems (MPS) with human study data. We will characterize and standardize all
MPS models through multi-omics analysis, placing these…
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