grant
Biogenesis of bacterial outer membrane proteins
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AccelerationAffinityAlanineAntibiotic AgentsAntibiotic DrugsAntibioticsAntigensAutoregulationB pertussisB. pertussisBacterial InfectionsBacterial Outer Membrane ProteinsBeta SheetBindingBiogenesisBiologicalBiologyBioremediationsBordetella pertussisCell BodyCell FunctionCell Membrane LipidsCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessClientCyclic PeptidesDNA mutationDataE coliE. coliEnvironmentEscherichia coliExhibitsGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGlnGlutamineGlycolipidsGoalsGram-Negative BacteriaGrowthH PertussisH-bondH. PertussisHaemophilus pertussisHomeostasisHydrogen BondingIn VitroIntegral Membrane ProteinIntrinsic Membrane ProteinL-GlutamineLateralLibrariesLipid BilayersLipidsLipopolysaccharidesMediatingMembraneMembrane LipidsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMessenger RNAMiscellaneous AntibioticModelingMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMutationNutrientOMP ProteinsOrigin of LifePathogenicityPathogenicity FactorsPeptidesPhysiological HomeostasisPlayPropertyProteinsQ LevoglutamideQ. LevoglutamideReactionReportingRoleSideSiteSodium ChlorideStructureSubcellular ProcessSurfaceSurface ProteinsTM DomainTRAP PeptideTechnologyTherapeuticThrombin Receptor Activating Peptide LigandThrombin Receptor Activating PeptidesThrombin Receptor Activator PeptideTissue GrowthTransmembrane DomainTransmembrane ProteinTransmembrane Protein GeneTransmembrane RegionVaccine AntigenVaccinesVesicleVirulenceVirulence Factorsalpha helixbacteria infectionbacterial diseasebeta barrelbeta pleated sheetbiologicclinical developmentconformationconformationalconformational stateconformationallyconformationsextracellulargenome mutationhydrophilicityimmunogenin vivoinhibitorinsightinterestlipid bilayer membranemRNAmembermembrane structuremolecular dynamicsmutantnovelontogenypertactinpolypeptideprotein functionproteoliposomessaltscreeningscreeningssocial roleuptakeα-helixβ-Sheetβ-pleated sheet
Description preview
Recently, we have devoted considerable effort to determining the role of lipids in the assembly (membrane insertion and folding) of OMPs. This project emerged from our discovery that the assembly of OmpC (an E. coli OMP that forms homotrimers) into lipid vesicles that contain purified BAM (BAM proteoliposomes) requires lipopolysaccharide (LPS).…
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