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Biofluid Core
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 15 Sept 2019Deadline 14 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY2024(TNF)-αAD related dementiaADRDAcademiaAddressAlzheimer's and related dementiasAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Biological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood SerumBlood specimenC3bC9ORF72CachectinCatalogingCell LineCellLineClinicClinicalClinical TrialsCollaborationsCollectionCommunitiesComplement 3bComplement C3bDNADataData Base ManagementData Base Management SystemsData BasesDatabase Management SystemsDatabasesDeoxyribonucleic AcidDiagnosisDipeptidesDiseaseDisorderEarly DiagnosisEquipment and supply inventoriesExperimental ModelsFTLDFamilyFrontotemporal Lobar DegenerationsFrontotemporal variety lobar degenerationGenesGenetic AlterationGenetic ChangeGenetic defectGoalsHPGFHepatocyte-Stimulating FactorHigh PrevalenceHigh Throughput AssayHybridoma Growth FactorIFN-Gamma-Inducing Factor GeneIFN-beta 2IFN-gamma-Inducing FactorIFNB2IGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-18IL-18 GeneIL-1gIL-1g GeneIL-6IL18IL18 ProteinIL18 geneIL1F4IL1F4 GeneIL6 ProteinIndustryIndustry CollaborationIndustry CollaboratorsInflammatoryInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-6InterventionIntervention StrategiesInventoryInvestigatorsLifeLightLiquid substanceMGC12320MGC12320 GeneMGI-2MT-bound tauMacrophage-Derived TNFMeasurementMeasuresMessenger RNAMonitorMonocyte-Derived TNFMutationMyeloid Differentiation-Inducing ProteinNINDSNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNerve DegenerationNeuron DegenerationPBMCPC cell-derived growth factorPCDGFPGRN genePGRN proteinParticipantPathologicPathologyPatientsPeripheral Blood Mononuclear CellPhotoradiationPlasmaPlasma SerumPlasmacytoma Growth FactorPopulationPrevention trialProgranulinProteinsQualifyingResearch PersonnelResearch SpecimenResearchersReticuloendothelial System, Serum, PlasmaRoleSamplingSensitivity and SpecificitySerumSpecimenStandardizationStrains Cell LinesStratificationSyndromeSystemTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTherapeuticTumor Necrosis FactorTumor Necrosis Factor-alphaWashingtonaccurate diagnosisautosomal dominant mutationbehavioral variant FTDbehavioral variant frontotemporal degenerationbehavioral variant frontotemporal dementiabio-markersbiobankbiologic markerbiomarkerbiomarker discoverybiorepositorybvFTDcarrier statuschromosome 9 open reading frame 72clinical trial participantcultured cell linedata basedata managementdata sharingdatabase managementdatabase systemsdepositorydrug discoveryearly detectionfluidgenome mutationgranulin precursorhigh throughput screeningiPSiPSCiPSCsimprovedinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent stem cellinterferon beta 2intervention effectinterventional strategyliquidmRNAmicrotubule bound taumicrotubule-bound tauneural degenerationneurodegenerationneurodegenerativeneurofilamentneurological degenerationneuronal degenerationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpharmacodynamic biomarkerpharmacodynamic markerprogranulin geneprogranulin proteinrelational database management systemsrepositorysample collectionsocial rolespecimen collectiontautau Proteinstau factortherapeutic agent developmenttherapeutic biomarkertherapeutic developmenttherapeutic markertherapeutic targettooltreatment effectτ Proteins
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Description preview
ABSTRACT – ARTFL LEFFTDS Longitudinal FTLD: BIOFLUID CORE
Successful treatment of Frontotemporal Lobar Degeneration (FTLD) will require early and accurate diagnosis,
and the ability to monitor the effects of novel interventions in clinical trials. An overarching goal of ALLFTD is to
generate a well-characterized population of potential clinical…
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