grant
Bioengineering Tools to Resolve and Manipulate Neuroimmune Signaling
Organization ARIZONA STATE UNIVERSITY-TEMPE CAMPUSLocation SCOTTSDALE, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2023AD dementiaAccelerationAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAutophagocytosisBindingBiologic ModelsBiological FunctionBiological ModelsBiological ProcessBiologyBiomedical EngineeringBody TissuesBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsChimeraChimera organismDegenerative Neurologic DiseasesDegenerative Neurologic DisordersDiseaseDisease ProgressionDisease modelDisorderEncephalonEngineeringGene DeliveryGenesGenetic ModelsHortega cellHumanHuman EngineeringImageImplantInfectionInflammationIntracellular Communication and SignalingMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental disordersMental health disordersMethodsMiceMice MammalsMicrogliaModalityModel SystemModern ManMolecular InteractionMurineMusNMR ImagingNMR TomographyNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeuroimmuneNeurologic Degenerative ConditionsNuclear Magnetic Resonance ImagingParalysis AgitansParkinsonParkinson DiseasePathologyPrimary ParkinsonismPrimary Senile Degenerative DementiaPsychiatric DiseasePsychiatric DisorderReporterResearchResolutionRoleSignal TransductionSignal Transduction SystemsSignalingTechnologyTherapeutic InterventionTissuesViral VectorZIKVZeugmatographyZika Virusautophagybio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductioncell typechimerasdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisorder modelgene manipulationgenetic manipulationgenetically manipulategenetically perturbgitter cellhumanized micehumanized mouseimagingimplantationin vivoin vivo Modelintervention therapymental illnessmesogliamicroglial cellmicrogliocyteneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatorynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-invasive imagingnoninvasive imagingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenperivascular glial cellprimary degenerative dementiapsychiatric illnesspsychological disorderresolutionsresponsesenile dementia of the Alzheimer typesensorsocial rolespatiotemporaltherapeutic evaluationtherapeutic testingtoolzikav
Description preview
PROJECT SUMMARY
Microglia have a role in nearly every incurable psychiatric and neurodegenerative disorder, but of all the
cell types in the brain, they remain the least tractable to study. Human cells in culture do not accurately
recapitulate microglial biology, yet mice have demonstrably non-human neuroimmune responses to pathogens
and disease…
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