grant
Bioenergetics of time-restricted feeding within the brain-adipose axis
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 5 Sept 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ARNTLARNTL geneAblationAccelerationAddressAdipocytesAdipose CellAdipose tissueAnimalsArginine VasopressinArgipressinAutomobile DrivingBMAL1BehavioralBioenergeticsBody CompositionBody TemperatureBody WeightBrainBrain Nervous SystemBreedingCRE RecombinaseCaloriesCell BodyCell Communication and SignalingCell SignalingCellsCircadian DysregulationCommunicationConsumptionCreatineD-GlucoseDarknessDextroseDiabetes MellitusDietDiseaseDisorderEatingEncephalonEndocrine Gland SecretionEnergy ExpenditureEnergy MetabolismEngineeringEnterobacteria phage P1 Cre recombinaseEpidemicEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFLP recombinaseFLP site-specific recombinaseFastingFat CellsFatsFatty TissueFatty acid glycerol estersFoodFood IntakeFutile CyclingFutile CyclingsFutile Substrate CyclingFutile Substrate CyclingsGEM modelGEMM modelGene TranscriptionGeneticGenetic TranscriptionGenetically Engineered MouseGenomic approachGlucoseHealthHealth BenefitHeat ProductionHigh Fat DietHormonesHuB219Hypothalamic structureHypothalamusImpairmentIndividualIntermediary MetabolismIntracellular Communication and SignalingLEP-RLEPR ProteinLightLinkLipidsLipocytesMature LipocyteMature fat cellMediatingMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsModelingMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuroendocrineNeuroendocrine SystemNeuronsNeurosecretory SystemsOB ReceptorOB-RObesityObesity EpidemicOrganPatternPhasePhotoradiationRNA ExpressionRegulationRestRiskSignal TransductionSignal Transduction SystemsSignalingSleepSleep DeprivationTemperatureTestingTherapeutic HormoneThermogenesisThesaurismosisTimeTime-restricted eatingTime-restricted feedingTranscriptionVasopressin-Neurophysin II-CopeptinWeight GainWeight Increaseadiposeadiposityaryl hydrocarbon receptor nuclear translocator-likebacteriophage P1 recombinase Crebiological signal transductionbody weight gainbody weight increasebrain-adipocyte axiscircadiancircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercombatcorpulenceday shiftdeficient sleepdiabetesdiet-associated obesitydiet-induced obesitydiet-related obesitydietarydietsdrivingepigeneticallyexperiencefastedfastsfeedingfood Ingestionfood consumptiongene manipulationgenetic manipulationgenetically engineered mouse modelgenetically engineered murine modelgenetically manipulategenetically perturbgenomic effortgenomic strategyhypothalamichypothalamic-sympathoneural-adipocyte axisinadequate sleepinsightinsufficient sleepleptin receptorleptin-binding proteinmetabolism disordermetabolism measurementmetabolomicsmetabonomicsmolecular clockmouse modelmurine modelneurogeneticsneuronalnight shiftnight workobesity developmentpreventpreventingresponserestorationshift workshiftworksleep debtsleep deficiencysleep deficitsleep insufficiencysleep losswhite adipose tissuewt gainyellow adipose tissue
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Project Summary:
The increased risk of metabolic disorders in individuals subjected to shiftwork and those experiencing sleep loss
indicate that disruption of day/night behavioral rhythms represents an emerging factor in the linked epidemics of
obesity and diabetes. In mice, consumption of a high fat diet (HFD) leads to increased feeding during…
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