grant
Biochemical Mechanisms for Sustained Humoral Immunity
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 23 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20250-4 weeks old7S Gamma GlobulinATF6ATF6 geneActivating Transcription Factor 6AcuteAfter CareAfter-TreatmentAftercareAllelesAllelomorphsAntibodiesAntibody ResponseAntibody titer measurementApoptosisApoptosis PathwayApoptoticAutoantibodiesAutoimmune StatusAutoimmunityAutoregulationB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBiochemicalBlood Plasma CellBlood SerumBlood VesselsBone MarrowBone Marrow Blood-Deriving CellBone Marrow Blood-Forming CellBone Marrow CellsBone Marrow Reticuloendothelial SystemC/EBP homologous proteinCHOP proteinCHOP-10 proteinCXCL12CXCL12 geneCXCL12 proteinCationsCell BodyCell Communication and SignalingCell DeathCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessChemokine (C-X-C Motif) Ligand 12Chemotactic CytokinesConnexinsCre driverCuesDDIT3 proteinDNA damage-inducible transcript 3 proteinDNA mutationDataDiseaseDisorderDrugsER stressElementsEndothelial CellsEndotheliumExposure toFamilyFosteringGADD153 proteinGap Junction ProteinsGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisHealthHomeostasisHomingHomologous Chemotactic CytokinesHost DefenseHumanHumoral ImmunitiesIgAIgGImmunoglobulin AImmunoglobulin GIn SituIn VitroInfectionIntercrinesIntracellular Communication and SignalingLength of LifeLongevityMammaliaMammalsMediatingMedicationMetabolicMitochondriaModelingModern ManMolecular InteractionMutagenesisMutagenesis Molecular BiologyMutationNewborn InfantNewbornsOsteoblastsOutcomePBSFPathogenicityPathway interactionsPharmaceutical PreparationsPhysiological HomeostasisPlasma CellsPlasmacytesPlayPre-B Cell Growth Stimulating FactorProcessProgrammed Cell DeathProtein BiosynthesisPurine ReceptorsPurinergic ReceptorsPurinoceptorRegulationRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSCYB12SDF-1SDF-1ASDF-1BSDF-1alphaSDF1SDF1ASDF1BSIS cytokinesSdf1 proteinSerumSignal TransductionSignal Transduction SystemsSignalingSourceSpleenSpleen Reticuloendothelial SystemStromal Cell-Derived Factor 1Subcellular ProcessTLSF-ATLSF-BTPAR1TestingTransplantationVaccinationVaccinesWorkXBP1XBP1 geneantibody titeringantibody-based immunityautoimmune antibodyautoreactive antibodybiological signal transductionbonebone losscell typechemoattractant cytokinechemokinedrug/agentendoplasmic reticulum stressextracellulargenome mutationhIRHimprovedimproved outcomeinhibitorinsightmitochondrialnecrocytosisnew approachesnewborn childnewborn childrennovel approachesnovel strategiesnovel strategypathwayplasmocytepost treatmentpreventpreventingprotein synthesisresponserestraintself reactive antibodysocial rolestromal cell-derived factor-1alphatranscription factor CHOPtransplantvascular
Description preview
Project summary
Antibody-secreting plasma cells play critical roles in health and disease, yet little is known
about the biochemical mechanisms controlling antibody synthesis and secretion or how
these pathways intersect with pathways controlling cell survival. Furthermore, due to the
high metabolic demands inherent to robust antibody secretion…
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