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Bio-Click: A cell-free high-throughput platform for the engineering of enzymatic group transfer reactions

Organization INVIZYNE TECHNOLOGIES, INC.Location Monrovia, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20252-Phenyl-Benzopyrans2-Phenyl-ChromenesAI AugmentedAI assistedAI basedAI drivenAI enhancedAI integratedAI poweredAcetylationAcidsAlcohol Chemical ClassAlcoholsArchitectureArtificial Intelligence enhancedAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIBenignBiochemicalBiochemistryBiologicalBiological ChemistryBiomanufacturingCell BodyCellsCharacteristicsChemicalsChemistryCollectionComputational toolkitComputer ModelsComputerized ModelsDataData CollectionDevelopmentDevelopment and ResearchDimethylallyltransferaseDimethylallyltranstransferaseDolichyl Phosphate SynthetaseDonor ScreeningDonor SelectionEngineeringEngineering / ArchitectureEnvironmentEnzyme GeneEnzymesFarnesylpyrophosphate SynthetaseFlavonoidsFutureGenetics-MutagenesisGeranylgeranyl Pyrophosphate SynthetaseGeranylpyrophosphate SynthetaseGoalsHigh Throughput AssayIndole AlkaloidsIndolylethylaminesIndustryLibrariesMachine LearningMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicalMedicineMetabolic GlycosylationMethodsMethylationMutagenesisMutagenesis Molecular BiologyNatural ProductsNatureNerylpyrophosphate SynthetaseNutraceuticalPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePhosphorylationPilot ProjectsPlasmidsPrenyltransferasePreparationPreparednessProductionPropertyProtein BiochemistryProtein BiosynthesisProtein EngineeringProtein PhosphorylationProtein/Amino Acid BiochemistryProteinsPythonsR & DR&DRapid screeningReactionReadinessRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoboticsSBIRSamplingSiteSmall Business Innovation ResearchSmall Business Innovation Research GrantSolubilitySpinal ColumnSpineSystemTechnologyTestingTimeTryptaminesVariantVariationVertebral columnartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredbackbonebiologicbiological systemscloud basedcofactorcombinatorialcomputational modelingcomputational modelscomputational toolboxcomputational toolscomputational toolsetcomputer based modelscomputerized modelingcomputerized toolscostdata acquisitiondata acquisitionsdata analysis pipelinedata processing pipelinedata toolsdesigndesigningdevelopmentaldrug developmentdrug discoveryenhanced with AIenhanced with Artificial Intelligenceexpectationgenetic protein engineeringglycosylationhigh throughput screeningimprovedindustrial productionmachine based learningmolecular massnaturally occurring productnovelpharmaceuticalpharmacologicpilot studyprenylprenylationpreparationsproduct developmentprotein designprotein synthesisresearch and developmentscaffoldscaffoldingscreeningscreeningssuccesssugarsynthetic biologytechnology platformtechnology systemthermolabilitythermostabilitytool

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Project Abstract – Invizyne Technologies, Inc
Biocatalytic group transfer reactions are essential in all biological systems and have
emerged as powerful tools in synthetic biology and cell-free biomanufacturing. Their
characteristics and mechanisms bear striking similarity to click chemistry reactions (‘BioClick
Reactions’) and their ability to…

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